Abstract: Objective To evaluate different intervention methods on the efficacy of smoking cessation in order to support individualized and precise smoking cessation. Methods Data of 368 patients who visited the smoking cessation clinic at the Second Affiliated Hospital of Chongqing Medical University from October 2021 to October 2023 were collected and divided into outpatient group, WeChat group and outpatient+WeChat group according to their preferences. Statistical analysis of social demographic characteristics, smoking and smoking cessation status in each group was performed. Results At the third and sixth months, the WeChat group had the lowest smoking reduction rate, sustained smoking cessation rate, and 7-day point-prevalence abstinence rate in the third month, as well as the highest dropout rate (all P＜0.05); In the sixth month, the outpatient+WeChat group had the highest continuous smoking cessation rate and the WeChat group had the lowest (both P＜0.05). In the sixth month, the number of cigarette reduction in each group increased compared to before, with the outpatient+WeChat group having the highest number of cigarette reductions (P＜0.05). The degree of tobacco dependence decreased compared to before and the FTND and HSI scores of the WeChat group were higher than the other two groups (both P＜0.05). Age, degree of tobacco dependence, and completion of long-term follow-up were risk factors for successful smoking cessation (all P＜0.05). Conclusions Different methods can help quit smoking and the intervention effect of outpatient+WeChat group is the most effective one and the WeChat group is the weakest one.

Key words: smoking cessation clinic, strengthen smoking cessation intervention, 7-day smoking cessation rate, continuous smoking cessation rate, tobacco dependence