Progress in urinary metabolomics research technologies and applications in cancer diagnosis

doi:10.16352/j.issn.1001-6325.2025.08.0999

Abstract

Abstract: Urine metabolomics serves as a crucial approach for discovering non-invasive biomarkers. It enables the detection of metabolite variations during disease progression and therapeutic interventions, offering novel insights for early disease diagnosis, prevention, and personalized treatment. Compared to other bodily fluids, urine exhibits distinctive advantages, including ease of collection, metabolite abundance, and the capacity to promptly reflect biochemical metabolic pathway alterations in vivo. Strict adherence to standardized protocols for sample collection and preservation is imperative in urine metabolomics research. Nuclear magnetic resonance (NMR) and mass spectrometry (MS) are primary analytical techniques in urine metabolomics studies. Given the complex composition of urinary metabolites, appropriate analytical technologies should be selected based on specific research objectives, the combination of multiple techniques often employed to enhance the comprehensiveness and accuracy of metabolite analysis in samples. This review focuses on major technological advancements in urine metabolomics and their applications in biomarker discovery from cancer screening.

Key words: urinary metabolomics, nuclear magnetic resonance, mass spectrometry, cancer diagnosis

CLC Number:

CHEN Lingyun, CHEN Wensong, SUN Qinqiang, ZI Jin. Progress in urinary metabolomics research technologies and applications in cancer diagnosis[J]. Basic & Clinical Medicine, 2025, 45(8): 999-1009.

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