Role of macrophage extracellular traps in inflammatory diseases

doi:10.16352/j.issn.1001-6325.2025.10.1368

Abstract

Abstract: Macrophage extracellular traps (METs) are extracellular fibrous web-like structures produced by macrophages. Under physiological conditions, METs capture and kill microorganisms by releasing high concentrations of granular proteins, serving as an innate immune defense mechanism and playing a vital protective role in resisting the progression of inflammatory diseases. Excessive release of METs can also exacerbate the inflammatory response and cause further tissue damage.

Key words: macrophage, macrophage extracellular traps, inflammatory disease

CLC Number:

R364.7

WU Qianqian, MA Kaiting, CAO Lingfei, WANG Xiaoping. Role of macrophage extracellular traps in inflammatory diseases[J]. Basic & Clinical Medicine, 2025, 45(10): 1368-1371.

References

[1] Rasmussen KH, Hawkins CL. Role of macrophage extracellular traps in innate immunity and inflammatory disease[J]. Biochem Soc Trans, 2022, 50: 21-32.
[2] Carai P, González LF, Van Bruggen S, et al. Neutrophil inhibition improves acute inflammation in a murine model of viral myocarditis[J]. Cardiovasc Res, 2023, 118: 3331-3345.
[3] Mónaco A, Canales-Huerta N, Jara-Wilde J, et al. Salmonella typhimurium triggers extracellular traps release in murine macrophages[J]. Front Cell Infect Microbiol, 2021, 11: 639768. doi:10.3389/fcimb.2021.639768.
[4] Kang H, Liu T, Wang Y, et al. Neutrophil-macrophage communication via extracellular vesicle transfer promotes itaconate accumulation and ameliorates cytokine storm syndrome[J]. Cell Mol Immunol, 2024, 21: 689-706.
[5] Jiahui C, Jiadai Z, Nan Z, et al. Mir-19b-3p/pknox1 regulates viral myocarditis by regulating macrophage polarization[J]. Front Genet, 2022, 13: 902453. doi:10.3389/fgene.2022.902453.
[6] Baz AA, Hao H, Lan S, et al. Emerging insights into macrophage extracellular traps in bacterial infections[J]. FASEB J, 2024, 38: e23767 doi:10.1096/fj.202400739R.
[7] Matsumoto K, Yasuoka H, Yoshimoto K, et al. Platelet cxcl4 mediates neutrophil extracellular traps formation in anca-associated vasculitis[J]. Sci Rep, 2021, 11: 222. doi:10.1038/s41598-020-80685-4.
[8] Lu C, Wu Z, Gao H, et al. Sperm induce macrophage extracellular trap formation via phagocytosis-dependent mechanism[J]. Biol Reprod, 2023, 109: 319-329.
[9] Pertiwi KR, De Boer OJ, Mackaaij C, et al. Extracellular traps derived from macrophages, mast cells, eosinophils and neutrophils are generated in a time-dependent manner during atherothrombosis[J]. J Pathol, 2019, 247: 505-512.
[10] Conedera FM, Kokona D, Zinkernagel MS, et al. Macrophages coordinate immune response to laser-induced injury via extracellular traps[J]. J Neuroinflammation, 2024, 21: 68. doi:10.1186/s12974-024-03064-0.
[11] Yin K, Wang D, Zhang Y, et al. Polystyrene microplas-tics promote liver inflammation by inducing the formation of macrophages extracellular traps[J]. J Hazard Mater, 2023, 452: 131236. doi:10.1016/j.jhazmat.2023.131236.
[12] Liu Y, Carmona-Rivera C, Moore E, et al. Myeloid-specific deletion of peptidylarginine deiminase 4 mitigates atherosclerosis[J]. Front Immunol, 2018, 9: 1680. doi:10.3389/fimmu.2018.01680.
[13] Kim JK, Lee HW, Joo N, et al. Prognostic role of circulating neutrophil extracellular traps levels for long-term mortality in new end-stage renal disease patients[J]. Clin Immunol, 2020, 210: 108263. doi:10.1016/j.clim.2019.108263.
[14] Aberle J, Lautenbach A, Meyhöfer S, et al. Obesity and diabetes[J]. Exp Clin Endocrinol Diabetes, 2024, 132: 232-239.
[15] Tong X, Wei L, Wang T, et al. Remodeling of macrophages in white adipose tissue under the conditions of obesity as well as lipolysis[J]. Oxid Med Cell Longev, 2021, 2021: 9980877. doi:10.1155/2021/9980877.
[16] Zhang X, Zhang L, Tan YM, et al. Hepcidin gene silencing ameliorated inflammation and insulin resistance in adipose tissue of db/db mice via inhibiting mets formation[J]. Mol Immunol, 2021, 133: 110-121.
[17] 黄赛赛, 孙玥, 陈子嫣,等.巨噬细胞胞外诱捕网在类风湿关节炎患者滑膜中的表达及其临床意义[J]. 临床检验杂志,2022,40: 330-335.
[18] Goff SH, Bergstedt DT, Feser ML, et al. Multi-autoantibody testing identifies expansion of reactivity to targeted antigens before a diagnosis of rheumatoid arthritis[J]. ACR Open Rheumatol, 2024, 6: 587-597.
[19] Ricardo-Gonzalez RR, Kotas ME, O'leary CE, et al. Innate type 2 immunity controls hair follicle commensalism by demodex mites[J]. Immunity, 2022, 55: 1891-1908.e1812.
[20] Sun M, Zhao Z, Li Y, et al. Giardia vspas7 protein attenuates giardia intestinalis-induced host macrophage pyroptosis[J]. Parasit Vectors, 2023, 16: 359. doi:10.1186/s13071-023-05949-0.
[21] Munoz-Caro T, Silva LM, Ritter C, et al. Besnoitia besnoiti tachyzoites induce monocyte extracellular trap formation[J]. Parasitol Res, 2014, 113: 4189-4197.
[22] Xu SS, Li H, Li TJ, et al. Neutrophil extracellular traps and macrophage extracellular traps predict postoperative recurrence in resectable nonfunctional pancreatic neuroendocrine tumors[J]. Front Immunol, 2021, 12: 577517. doi:10.3389/fimmu.2021.577517.
[23] Chen T, Wang Y, Nan Z, et al. Interaction between macrophage extracellular traps and colon cancer cells promotes colon cancer invasion and correlates with unfavorable prognosis[J]. Front Immunol, 2021, 12: 779325. doi:10.3389/fimmu.2021.779325.