Abstract: Objective To explore the diagnosis and treatment experience of malignant peritoneal mesothelioma by analyzing the clinical characteristics of patients with single center peritoneal mesothelioma. Methods Retrospectively analyze the clinical data, including age and treatment regimens, of 99 patients with malignant peritoneal mesothelioma admitted to Peking Union Medical College Hospital from June 2012 to July 2023. Kaplan-Meier for survival analysis and Logistic and Cox regression were applied to assess the impact of factors like age and treatment regimens on survival time. Results The median age of diagnosis for 99 patients with peritoneal mesothelioma was 56 years, of which 82 were pathologically diagnosed. Among them, 38 cases (51.4%) underwent tumor cell reduction surgery, and 57 cases (77.0%) underwent systemic or local treatment. The median survival time for all patients was 43 years. The age of diagnosis may affect the prognosis of patients with malignant mesothelioma, and those aged ≥65 at the time of diagnosis have a worse prognosis. Conclusions Malignant peritoneal mesothelioma is a rare but invasive malignant tumor with a poor prognosis. There is still a need to develop novo drugs and comprehensive treatment strategies.

Key words: peritoneal mesothelioma, cytoreductive surgery, peritoneal heat infusion chemotherapy, chemotherapy