Treatment of antibody-drug conjugates in elderly patients

doi:10.16352/j.issn.1001-6325.2025.10.1270

Abstract

Abstract: Antibody-drug conjugates(ADCs) are emerging anti-cancer drugs that have been widely applied in the treatment of hematological and solid tumors. ADCs deliver cytotoxic drugs to tumor cells with precision through antibody targeting, enhancing efficacy while reducing side effects. Elderly cancer patients face treatment challenges due to factors such as drug metabolism, multiple comorbidities and decreased physical function. However, ADCs have therapeutic advantages in elderly patients. The article discusses the efficacy, safety, dosing strategies, and adverse reaction management of ADCs in elderly patients, in order to provide effective and safe treatment options for elderly cancer patients.

Key words: antibody-drug conjugates, elder patients, cancer treatment, targeted therapy

CLC Number:

R730.5

LIU Fengshuo, GUAN Mei. Treatment of antibody-drug conjugates in elderly patients[J]. Basic & Clinical Medicine, 2025, 45(10): 1270-1276.

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