Advances in the treatment of dental stem cells for Parkinson′s disease

doi:10.16352/j.issn.1001-6325.2024.09.1298

Abstract

Abstract: Parkinson′s disease (PD) is the second most common neurodegenerative disease, mainly due to the loss of dopaminergic neurons in the substantia nigra (SN) of the midbrain, resulting in motor dysfunction. Dental stem cells (DSCs) are derived from the cranial neural crest which can be easily harvested. DSCs coming from the cranial neural crest have excellent proliferation and differentiation ability, and can promote nerve repair and regeneration. DSCs can secrete new dopamine neurons and secrete a large number of neurotrophic factors(NTFs) to improve the neural function, and also inhibit the neuroinflammatory response through immune modulation. DSCs can effectively alleviate the motor dysfunction in rats with PD and play an important role in R&D of regenerative medicine.

Key words: dental pulp stem cell, stem cells from human exfoliated deciduous teeth, neurodegenerative disease, Parkinson ′s disease, exosome

CLC Number:

YU Manshu, ZHAO Xiaomin, QIU Mingyue, LIU Chunran, NA Risu. Advances in the treatment of dental stem cells for Parkinson′s disease[J]. Basic & Clinical Medicine, 2024, 44(9): 1298-1302.

References 25

[1]	Huang T, Wang XX, Gao CY, et al. Motor symptoms of Parkinson′s disease are affected by temperature: a controlled pilot study[J]. Brain Behav. 2024, 14:e3369. doi: 10.1002/brb3.3369.
[2]	Ueda T, Inden M, Ito T, et al. Characteristics and therapeutic potential of dental pulp stem cells on neurodegenerative diseases[J]. Front Neurosci, 2020, 14:407.doi:10.3389/fnin.2020.00407.
[3]	Yu Z, Xu N, Zhang N, et al. Repair of peripheral nerve sensory impairments via the transplantation of bone marrow neural tissue-committed stem cell-derived sensory neurons[J]. Cell Mol Neurobiol, 2019, 39:341-353. doi: 10.1007/s10571-019-00650-2.
[4]	Jin MH, Chen DQ, Jin YH, et al. Hispidin inhibits LPS-induced nitric oxide production in BV-2 microglial cells via ROS-dependent MAPK signaling[J]. Exp Ther Med, 2021, 22:970. doi: 10.3892/etm.2021.10402.
[5]	徐娅冬, 李雅丽, 黄魏宁. 呼出气一氧化氮对变应性鼻炎伴哮喘患者鼻用激素治疗的指导价值[J].中国耳鼻咽喉头颈外科, 2023, 30:398-400. doi:10.16066/j.1672-7002.2023.06.014.
[6]	孙悦, 赵艳春, 张婷, 等. 一氧化氮对鱼藤酮诱导神经细胞损伤的调节作用[J]. 石河子大学学报(自然科学版), 2021,39:225-233. doi:10.13880/j.cnki.65-1174/n.2021.22.012.
[7]	Bytowska ZK, Korewo-Labelle D, Kowalski K, et al. Impact of 12 weeks of vitamin D3 administration in Parkinson′s patients with deep brain stimulation on kynurenine pathway and inflammatory status[J]. Nutrients, 2023, 15:3839. doi: 10.3390/nu15173839.
[8]	Gu C, Wang F, Zhang YT, et al. Microglial MT1 activation inhibits LPS-induced neuroinflammation via regulation of metabolic reprogramming[J]. Aging Cell, 2021, 20:e13375.doi:10.111/acel.13375.
[9]	Li B, Ouchi T, Cao Y, et al. Dental-derived mesen-chymal stem cells: state of the art[J]. Front Cell Dev Biol, 2021, 9:654559. doi: 10.3389/fcell.2021.654559.
[10]	Nishii T, Osuka K, Nishimura Y, et al. Protective mechanism of stem cells from human exfoliated deciduous teeth in treating spinal cord injury[J]. J Neurotrauma, 2024, 23. doi: 10.1089/neu.2023.0251.
[11]	Apel C, Forlenza OV, Paula VJR de, et al. The neuroprotective effect of dental pulp cells in models of Alzheimer′s and Parkinson′s disease[J]. J. Neural Transm, 2009, 116:71-78.
[12]	Cova L, Bossolasco P, Armentero MT, et al. Neuroprotective effects of human mesenchymal stem cells on neural cultures exposed to 6-hydroxydopamine: implications for reparative therapy in Parkinson′s disease[J]. Apoptosis, 2012, 17:289-304.
[13]	Zhang N, Lu XJ, Wu SC, et al. Intrastriatal transplanta-tion of stem cells from human exfoliated deciduous teeth reduces motor defects in Parkinsonian rats[J]. Cytotherapy, 2018, 20:670-686.
[14]	Lei T, Xiao ZZ, Zhang XS, et al. Human gingival mesenchymal stem cells improve movement disorders and tyrosine hydroxylase neuronal damage in Parkinson disease rats[J]. Cytotherapy, 2022, 24:1105-1120.
[15]	Liu Q, Gao Y, He JZ. Stem cells from the apical papilla (SCAPs): past, present, prospects, and challenges[J]. Biomedicines, 2023, 11:2047.doi: 10.3390/biomedicines11072047.
[16]	Xiao L, Nasu M. From regenerative dentistry to regenera-tive medicine: progress, challenges, and potential applications of oral stem cells[J]. Stem Cells Cloning, 2014, 7:89-99.
[17]	Mohebichamkhorami F, Fattahi R, Niknam Z, et al. Periodontal ligament stem cells as a promising therapeutic target for neural damage[J]. Stem Cell Res Ther, 2022, 13:273.doi:10.1186/s13287-022-02942-9.
[18]	Mohebichamkhorami F, Niknam Z, Khoramjouy M, et al. Brain homogenate of rat model of alzheimer disease modifies secretome of 3D cultured periodontal ligament stem cells a potential neuroregenerative therapy[J]. Iran J Pharm Res, 2022, 21:e133668. doi:10.5812/ijpr-133668.
[19]	Yang JQ, Wang BX, Wang YT, et al. Exosomes derived from adipose mesenchymal stem cells carrying miRNA-22-3p promote schwann cells proliferation and migration through downregulation of PTEN[J]. Dis Markers, 2022, 2022:7071877.doi:10.1155/2022/7071877.
[21]	Hanss Z, Larsen SB, Antony P, et al. Mitochondrial and clearance impairment in p.D620N VPS35 patient-derived neurons[J]. Mov Disord, 2021, 36:704-715. doi:10.1002/mds.28365.
[22]	Shiraishi T, Bono K, Hiraki H, et al. The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson′s disease[J]. Cell Mol Life Sci, 2024, 81:103. doi: 10.1007/s00018-024-05123-4.
[23]	Liu H, Kuang H, Wang Y, et al. MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation[J]. Biol Res, 2024,57:3. doi: 10.1186/s40659-023-00475-w.
[24]	Shi X, Yang G, Liu MY, et al. Exosomes derived from human dental pulp stem cells increase flap survival with ischemia-reperfusion injuries[J]. Regen Med, 2023, 18:313-327. doi: 10.2217/rme-2022-0206.
[25]	Chai Y, Liu Y, Liu Z, et al. Study on the role and mechanism of exosomes derived from dental pulp stem cells in promoting regeneration of myelin sheath in rats with sciatic nerve injury[J]. Mol Neurobiol, 2024. doi: 10.1007/s12035-024-03960-9.