Abstract: Objective To investigate the clinical effect of pyrimidolast potassium combined with praprofen eye drops in the treatment of allergic conjunctivitis(AC). Methods From March 2021 to March 2023, 186 patients with AC were selected from Beijing Gulou Hospital of Traditional Chinese Medicine.The patients were randomly assigned to a observation group and a control group with 93 in each. Pyrimidolast potassium eye drops (1-2 drops, b.i.d,) was given to both groups, and praprofen eye drops (1-2 drops, q.i.d) was given only to the observation group. Both groups of patients were treated for 14 days. Clinical symptoms, signs scores, tear film stability and corneal epithelium injury were compared between the two groups. Results After treatment,the total effective rate of observation group(93.54%) was higher than that of control group(80.65%). Symptom scores in observation group and control group were 0.19±0.66 and 0.70±0.69, respectively. The scores of physical signs were 0.09±0.51 and 0.42±0.40, respectively. Tear film stability was 10.81±2.58 and 9.39±1.87, respectively. The injury of corneal epithelium was 0.98±0.46 and 2.05±0.90, respectively, and the difference was statistically significant(P＜0.05). Conclusions Compared with the patients treated with pyriferast potassium eye drops only, the combined application of pralprofen eye drops can synergically enhance the efficacy of drugs, improve the symptoms and signs of patients, effectively repair corneal injury and stabilize tear film.

Key words: allergic conjunctivitis, pyrimidolast potassium, praprofeneye drops