Research progress on the role of ferroptosis in the pathogenesis of non-alcoholic fatty liver disease

doi:10.16352/j.issn.1001-6325.2024.02.0260

Abstract

Abstract: Ferroptosis is a new type of cell death proposed in recent years, and its main characteristics are iron overload and lipid peroxidation. Ferroptosis is involved in the occurrence and development of non-alcoholic fatty liver disease(NAFLD). Iron overload can generate a large amount of reactive oxygen species through the Fenton reaction. Under the action of lipoxygenase, the unsaturated fatty acids on the liver cell membrane undergo lipid peroxidation, which induces liver cell death and leads to the occurrence of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. Blocking ferroptosis may provide one of the therapeutic strategies to protect liver cells.

Key words: ferroptosis, non-alcoholic fatty liver disease, lipid peroxidation, iron overload

CLC Number:

R589.2

XIAO Yanxin, LIU Yan, XU Lingling, ZHOU Yaru. Research progress on the role of ferroptosis in the pathogenesis of non-alcoholic fatty liver disease[J]. Basic & Clinical Medicine, 2024, 44(2): 260-264.

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