Immunoglobulin is valuable in the differential diagnosis of primary biliary cholangitis, hepatitis E and cirrhosis

doi:10.16352/j.issn.1001-6325.2023.08.1271

Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (8): 1271-1274.doi: 10.16352/j.issn.1001-6325.2023.08.1271

• Clinical Sciences • Previous Articles Next Articles

Immunoglobulin is valuable in the differential diagnosis of primary biliary cholangitis, hepatitis E and cirrhosis

XING Xuemei¹, YANG Jianrui¹, LI Zhijun¹, CHEN Yajuan¹, YAO Fengxia², LIU Zheng^3,4*

1. Department of Medical Laboratory, the 3201st Hospital Affiliated to Medical College of Xi'an Jiaotong University, Hanzhong 723000;
2. Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, CAMS ＆ PUMC, Beijing 100730;
3. College of Medical Laboratory Science, Guilin Medical University, Guilin 541004;
4. Department of Medical Laboratory, Guihang Guiyang Hospital Affiliated to Zunyi Medical University, Guiyang 550027, China

Received:2022-06-10 Revised:2022-10-11 Online:2023-08-05 Published:2023-07-26
Contact: ^*zliu1111@163.com

Abstract

Abstract: Objective To explore the value of immunoglobulin in differential diagnosis of primary biliary cholangitis (PBC), hepatitis E and liver cirrhosis. Methods Blood samples were collected from 121 patients with PBC and 107 healthy people. The serum r-glutamyltransferase (r-GT), alkaline phosphatase (ALP), immunoglobulin IgG and IgM, total cholesterol (TCH) and lipoprotein (a)[Lp(a)] were detected by biochemical routine tests; Blood routine counted white blood cells (WBC) and platelets (PC); The IgG and IgM antibodies of HEV were detected by enzyme-linked immunosorbent assay (ELISA). Results r-GT, ALP, IgG and IgM in PBC patients increased significantly (P＜0.05) accompanied by significant decrease in WBC and PC values (P＜0.05). In patients with PBC cirrhosis, IgG increased significantly (P＜0.05), while WBC and PC values decreased significantly(P＜0.05). IgG and IgM in patients with PBC+cirrhosis+HEV antibody positive increased significantly(P＜0.05), while WBC and PC values decreased significantly (P＜0.05). Conclusions The increase of IgG and IgM might be used as diagnostic markers for the development of cirrhosis in PBC patients with HEV infection.

Key words: hepatitis E, primary biliary cholangitis, cirrhosis, IgG, IgM

CLC Number:

XING Xuemei, YANG Jianrui, LI Zhijun, CHEN Yajuan, YAO Fengxia, LIU Zheng. Immunoglobulin is valuable in the differential diagnosis of primary biliary cholangitis, hepatitis E and cirrhosis[J]. Basic & Clinical Medicine, 2023, 43(8): 1271-1274.

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Immunoglobulin is valuable in the differential diagnosis of primary biliary cholangitis, hepatitis E and cirrhosis

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