Research progress on the role of microRNA in diabetic osteoporosis

doi:10.16352/j.issn.1001-6325.2023.02.311

Abstract

Abstract: Diabetic osteoporosis (DOP) is a common bone metabolic disease in patients with diabetes. Under the high glucose (HG) environment, abnormally expressed microRNA (miRNA) interferes with osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) by regulating key molecules in the Wnt/β-catenin signaling pathway, leading to the occurrence and development of DOP. Exploring the role of miRNA in DOP can provide new ideas for the diagnosis and treatment of DOP.

Key words: diabetes mellitus, osteoporosis, microRNAs, Wnt signaling pathway, mesenchymal stem cells

CLC Number:

R580
R587.2

YANG Mengdi, DING Yulu, WANG Yujie, HE Fengying, SUN Linnan, ZHEN Donghu. Research progress on the role of microRNA in diabetic osteoporosis[J]. Basic & Clinical Medicine, 2023, 43(2): 311-316.

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