Research progress of stem cells aging

doi:10.16352/j.issn.1001-6325.2022.08.1288

Abstract

Abstract: Stem cells have broad therapeutic potential in many fields and have been used as seed cells in regenerative medicine and tissue engineering research. However, stem cell aging is a challenge to their clinical applications. By performing effective therapeutic interventions for aging stem cells, stem cells will bring greater hope for clinical practice. This review summarizes the latest advances in stem cells biology, so to delay aging of stem cells by potential intervention to the aging process. The results of research in this field will contribute to the development of new rational treatment strategies.

Key words: stem cells, stem cell aging, anti-aging

CLC Number:

ZHU Si-lu, LUO Dan. Research progress of stem cells aging[J]. Basic & Clinical Medicine, 2022, 42(8): 1288-1291.

References 20

[1]	Schultz MB, Sinclair DA. When stem cells grow old:phenotypes and mechanisms of stem cell aging[J]. Development, 2016,143:3-14.
[2]	Kim J, Vaish V, Feng M, et al. Transgenic expression of cyclooxygenase-2 (COX2) causes premature aging phenotypes in mice[J]. Aging, 2016,8:2392-2406.
[3]	Hegab AE, Ozaki M, Meligy FY, et al. High fat diet activates adult mouse lung stem cells and accelerates several aging-induced effects[J]. Stem Cell Res, 2018,33:25-35.
[4]	Parihar M, Dodds SG, Javors M, et al. Sex-dependent lifespan extension of FAP mice by chronic mTOR inhibition[J]. Aging Pathobiol Ther, 2020,2:187-194.
[5]	Yu X, He Y, Chen Z, et al. Autologous decellularized extracellular matrix protects against H2O2-induced senescence and aging in adipose-derived stem cells and stimulates proliferation in vitro[J]. Biosci Rep, 2019,39:BSR20182137. doi:10.1042/BSR20182137.
[6]	Zhang K, Liu F, Jin D, et al. Autophagy preserves the osteogenic ability of periodontal ligament stem cells under high glucose conditions in rats[J]. Arch Oral Biol, 2019,101:172-179.
[7]	Emmi G, Mannucci A, Argento FR, et al. Stem-cell-derived circulating progenitors dysfunction in behçet's syndrome patients correlates with oxidative stress[J]. Front Immunol, 2019,10:2877. doi:10.3389/fimmu.2019.02877.
[8]	Ogrodnik M, Zhu Y, Langhi LGP, et al. Obesity-induced cellular senescence drives anxiety and impairs neuro-genesis[J]. Cell Metab, 2019,29:1061-1077.
[9]	Liao N, Shi Y, Zhang C, et al. Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion[J]. Stem Cell Res Ther, 2019,10:306.doi:10.1186/s13287-019-1404-9.
[10]	Singh A, Yadav CB, Tabassum N, et al. Stem cell niche:dynamic neighbor of stem cells[J]. Eur J Cell Biol, 2019,98:65-73.
[11]	Maharajan N, Vijayakumar K, Jang CH, et al. Caloric restriction maintains stem cells through niche and regulates stem cell aging[J]. J Mol Med, 2020,98:25-37.
[12]	Ullah M, Sun Z. Klotho deficiency accelerates stem cells aging by impairing telomerase activity[J]. J Gerontol A Biol Sci Med Sci, 2019,74:1396-1407.
[13]	Bian A, Neyra JA, Zhan M, et al. Klotho, stem cells, and aging[J]. Clin interv Aging, 2015,10:1233-1243.
[14]	de Haan G, Lazare SS. Aging of hematopoietic stem cells[J]. Blood, 2018,131:479-487.
[15]	Tan DQ, Suda T. Reactive oxygen species and mitochondrial homeostasis as regulators of stem cell fate and function[J]. Antioxid Redox Signal, 2018,29:149-168.
[16]	Onodera Y, Teramura T, Takehara T, et al. miR-155 induces ROS generation through downregulation of antioxidation-related genes in mesenchymal stem cells[J]. Aging Cell, 2017,16:1369-1380.
[17]	Denu RA, Hematti P. Effects of oxidative stress on mesenchymal stem cell biology[J]. Oxid Med Cell Longev, 2016,2016:2989076.doi:10.1155/2016/2989076.
[18]	Keyes BE, Fuchs E. Stem cells:aging and transcriptional fingerprints[J]. J Cell Biol, 2018,217:79-92.
[19]	Fang JF, Huang XN, Han XY, et al. Combined transplantation of mesenchymal stem cells and endothelial progenitor cells restores cavernous nerve injury-related erec-tile dysfunction[J]. J Sex Med, 2018,15:284-295.
[20]	Dubey NK, Wei HJ, Yu SH, et al. Adipose-derived stem cells attenuates diabetic osteoarthritis via inhibition of glycation-mediated inflammatory cascade[J]. Aging Dis, 2019,10:483-496.