Research progress of acidic nucleoplasmic DNA-binding protein 1

Abstract

Abstract: Acidic nucleoplasmic DNA-binding protein 1 (And-1/WDHD1) as a natural chimerical protein, is characterized by containing the WD-repeat and the HMG-box motif families. And-1 is over-expressed in multiple tumors and involved in the whole cell cycle containing prereplication complex (Pre-RC) assembly, DNA replication, checkpoint activation, DNA repair and sister chromatid cohesion establishment. As a novel target for cell cycle regulation, And-1 can be used in the development of broad-spectrum anti-cancer drugs. This article focuses on the research on the structural characteristics, biochemical functions and potential roles of And-1 in cancer in recent years, in order to provide references for the further research of And-1 and the development of new drugs.

Key words: acidic nucleoplasmic DNA-binding protein 1(And-1), WD40(WD-repeat), high mobility group(HMG), novel target

CLC Number:

CUI Ya-ting, GOU Wen-feng, WEI Hui-qiang, YU Jiang, HOU Wen-bin, LI Yi-liang. Research progress of acidic nucleoplasmic DNA-binding protein 1[J]. Basic & Clinical Medicine, 2021, 41(5): 753-757.

References

[1] Guan CC, Li J, Sun DP, et al. The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome[J]. J Biol Chem, 2017, 292: 9627-9636.
[2] Williams DR, McIntosh JR. Mcl1⁺, the Schizosaccharomyces pombe homologue of CTF4, is important for chromosome replication, cohesion, and segregation[J]. Eukaryot Cell, 2002, 1: 758-773.
[3] Jain BP, Pandey S. WD40 repeat proteins: signalling scaffold with diverse functions[J]. Protein J, 2018, 37: 391-406.
[4] Bollaert E, De Rocca Serra A, Demoulin JB. The HMG box transcription factor HBP1: a cell cycle inhibitor at the crossroads of cancer signaling pathways[J]. Cell Mol Life Sci, 2019, 76: 1529-1539.
[5] Köhler A, Schmidt-Zachmann MS, Franke WW. AND-1, a natural chimeric DNA-binding protein, combines an HMG-box withregulatory WD-repeats[J]. J Cell Sci, 1997, 110: 1051-1062.
[6] Kilkenny ML, Simon AC, Mainwaring J, et al. The human CTF4-orthologue AND-1 interacts with DNA polymerase a/primase via its unique C-terminal HMG box[J]. Open Biol, 2017, 7: 1-14.
[7] Schapira M, Tyers M, Torrent M, et al. WD40 repeat domain proteins: a novel target class[J]. Nat Rev Drug Discov, 2017, 16: 773-786.
[8] Simon AC, Zhou JC, Perera RL, et al. A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome[J]. Nature, 2014, 510: 293-297.
[9] Blair RH, Horn AE, Pazhani Y, et al. The HMGB1 C-terminal tail regulates DNA bending[J]. J Mol Biol, 2016, 428: 4060-4072.
[10] Belgrano FS. Role of the acidic tail of high mobility group protein B1 (HMGB1) in protein stability and DNA bending[J]. PLoS One, 2013, 8: 1-12.
[11] Vizoso-Vázquez A, Barreiro-Alonso A, González-Siso MI, et al. HMGB proteins involved in TOR signaling as general regulators of cell growth by controlling ribosome biogenesis[J]. Curr Genet, 2018, 64: 1205-1213.
[12] Mandke P, Vasquez KM. Interactions of high mobility group box protein 1 (HMGB1) with nucleic acids: implications in DNA repair and immune responses[J]. DNA Repair, 2019, 83: 102701. doi: 10.1016/j.dnarep.2019.102701.
[13] Li Y, Xiao H, De Renty C, et al. The involvement of acidic nucleoplasmic DNA-binding protein (And-1) in the regulation of prereplicative complex (pre-RC) assembly in human cells[J]. J Biol Chem, 2012, 287: 42469-42479.
[14] Lan RF, Wang QQ. Deciphering structure, function and mechanism of lysine acetyltransferase HBO1 in protein acetylation, transcription regulation, DNA replication and its oncogenic properties in cancer[J]. Cell Mol Life Sci, 2020, 77: 637-649.
[15] Gambus A, Van Deursen F, Polychronopoulos D, et al. A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase α within the eukaryotic replisome[J]. EMBO J, 2009, 28: 2992-3004.
[16] Kang YH, Farina A, Bermudez VP, et al. Interaction between human Ctf4 and the Cdc45/Mcm2-7/GINS (CMG) replicative helicase[J]. Proc Natl Acad Sci U S A, 2013, 110: 19760-19765.
[17] Im JS, Ki SH, Farina A, et al. Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins[J]. Proc Natl Acad Sci U S A, 2009, 106: 15628-15632.
[18] Zhao F, Kim W, Kloeber JA, et al. DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells[J]. Exp Mol Med, 2020, 52: 1705-1714.
[19] Li YM, Li ZZ. Wu RQ, et al. And-1 is required for homologous recombination repair by regulating DNA end resection[J]. Nucleic Acids Res, 2017, 45: 2531-2545.
[20] Mozaffari NL, Pagliarulo F, Sartori AA. Human CtIP: A ‘double agent' in DNA repair and tumorigenesis[J]. Semin Cell Dev Biol, 2020. doi:10.1016/j.dnarep.2019.102701.
[21] Hao J, De Renty C, Li Y, et al. And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress[J]. EMBO J, 2015, 34: 2096-2110.
[22] Jaramillo-Lambert A, Hao J, Xiao HJ, et al. Acidic nucleoplasmic DNA-binding protein (And-1) controls chromosome congression by regulating the assembly of centromere protein A (CENP-A) at centromeres[J]. J Biol Chem, 2013, 288: 1480-1488.
[23] Sato N, Koinuma J, Fujita M, et al. Activation of WD repeat and high-mobility group box DNA binding protein 1 in pulmonary and esophageal carcinogenesis[J]. Clin Cancer Res, 2010, 16: 226-239.
[24] Gong L, Xiao MQ, He D, et al. WDHD1 leads to Cisplatin resistance by promoting MAPRE2 ubiquitination in lung adenocarcinoma[J]. Front Oncol, 2020, 10: 1-14.
[25] Chen YL, Liu HL, Zhang HX, et al. And-1 coordinates with CtIP for efficient homologous recombination and DNA damage checkpoint maintenance[J]. Nucleic Acids Res, 2017, 45: 2516-2530.