Abstract: Objective To explore the effect of case-based learning (CBL) combined with hypothalamus-pituitary MDT clinic in clinical teaching of hypothalamus pituitary diseases. Methods The trainees who participated in the hypothalamus-pituitary MDT discussion and CBL teaching in Peking Union Medical College Hospital from January to December 2019 were requird to fill in the questionnaire about the learning outcomes before and after participating in hypothalamus-pituitary MDT discussion and teaching. Likert 5 grade score method was used to evaluate the teaching effect. Results Among the 89 trainees,the degree of understanding of pituitary nonfunctional tumors, functional pituitary tumors, diabetes insipidus, differential diagnosis of pituitary stalk thickening, differential diagnosis of pituitary inflammatory diseases, and imaging knowledge of pituitary diseases before participating in hypothalamus-pituitary MDT were 41.57%, 48.31%, 49.44%, 12.36%, 12.36% and 23.60%, respectively. The degree of understanding increased to 74.16%, 76.40%, 82.02%, 73.03%, 78.65% and 86.52% respectively, and there was statistical difference after quantitative score (P＜0.01). Conclusions The teaching mode of hypothalamus-pituitary MDT based on CBL can improve the resident and attending physicians'knowledge about pituitary diseases. This teaching manner is expected to be applied in the clinical teaching of pituitary diseases.

Key words: multi-disciplinary team, case-based learning, hypothalamus-pituitary disease, questionnaire survey