Abstract: Neuroblastoma (NB) is one of the most common and deadly childhood solid tumors, originated from the medulla of the adrenal gland or the paravertebral sympathetic nervous system. Studies have shown that many genes are involved in the development of NB, in which ALK plays an important role in the pathogenesis of NB. The new targeted therapy based on ALK inhibitors has become a research hotspot in the treatment of NB. However, the mechanism of ALK in NB is not yet clear. Therefore, it is important to investigate the pathogenesis of ALK in NB, which can provide new ideas for targeted therapy of NB.

Key words: neuroblastoma, ALK gene, pathogenesis