Abstract: Objective To investigate the effects of clinical pharmacist intervention in the clinical application of antibiotics combined with the index management. Methods The data of antibiotics usage rate and intensity, the microbial test sample submission rate, and the clean incision preventive usage rate of inpatients and outpatients were analyzed by chi-square test in the same period before (2015) and after (2016) the clinical pharmacist intervention. Results After intervention, the antibiotics usage rate of inpatients and outpatients were lower than that of 2015 (50.02% and 25.72%, P<0.05). In 2016, the usage intensity of antibiotics was 50.59%, while it was 62.39% in 2015. At the same time, the microbial test sample submission rate increased from 13.96% to 27.49% (P<0.05).In 2016, the clean operation preventive usage rate of antibiotics decreased month by month. In the meantime, the reasonable rate of delivery timing, variety selection, and administration time of clean operation preventive usage of antibiotics were on the rise. Conclusion The professional intervention of clinical pharmacist is benefit for the routine, standardization, and professionalization of clinical antibiotics application.It also promotes the rational use of drugs and the progress of hospital pharmacy.

Key words: Key words: Clinical pharmacists, Intervention, Antimicrobial agents, Use, Effect analysis