Abstract: ATP-binding cassette transporter A1 (ABCA1) is an membrane protein,using ATP for transferring substances,modulated by liver X receptors(LXRs), retinoic X receptors(RXRs), sterol regulatory element binding proteins(SREBPs), microRNAs and other upstream modulators. ABCA1 plays an important role in multiple pathways related to lipid accumulation. Upregulating ABCA1 expression can reduce lipid accumulation, hence offers a promising strategy for metabolic diseases.

Key words: ABCA1, lipids, microRNAs