Abstract: Endometrial cancer(EC) is one of the most common gynecological cancer,of which the molecular biological mechanisms is very complex.In recent years, it has been reported that the abnormally regulated PI3K/Akt/mTOR signaling pathway is greatly related with endometrial cancer. The mutation and abnormal activation of the receptors and kinaseof the PI3K/Akt/mTOR signaling pathway may become the therapeutic target of endometrial cancer.

Key words: the PI3K/Akt/mTOR signaling pathway, gene mutations, endometrial cancer, targeted therapy