Abstract: Annexin A5 is a member of Ca2+-dependent Phospholipid Binding Proteins Family. It exists in histocytes. And because of its unique structure, Annexin A5 plays an important role in many critical functions such as cell inside/outside anticoagulation and pro-apoptosis. Moreover, Annexin A5 has certain relevance with many diseases such as systemic lupus erythematosus ,tumour and other diseases.

Key words: Annexin a5, Disease, Mechanism