Abstract: Objective To investigate the effect of TSA on lung cancer cell A549 and its possible mechanism. Methods Proliferation ability of A549 cells was detected by MTT assay; Migration of A549 cells was measured by Wound healing assay; The expression EMT markers proteins level were detected by Western blot. Results TSA significantly inhibited the proliferation of A549 cells(p<0.01). TSA inhibited A549 cells invasion and migration via inhibition of EMT. Conclusion TSA may effectively inhibit the ability of proliferation and migration of lung cancer, and the mechnism may be explained by inhibition of EMT.

Key words: trichostatin A, lung cancer, Epithelial-mesenchymal transition