Abstract: Recently, it has found that the expression of AEG-1 is elevated in subsets of various malignant cells. AEG-1 plays a potential role in several crucial aspects of oncogenesis, including cancer cell surviving, tumor progression, angiogenesis, antiapoptosis, invasion, metastasis and chemoresistance. Meanwhile, it has close relationship with inflammation and natural immunity. AEG-1 functions as a mediator of several signal pathways PI3K/Akt, NF-κB,Wnt/β-catenin. Moreover, it has found that AEG-1 participates in RNA-induced silencing complex mediating gene silencing. Therefore, AEG-1 may serve as an attractive molecular for clinical diagnosis and new anticancer agents target.

Key words: AEG-1, tumor, signal pathway, gene silence, inflammation