Abstract: Objective To study anxiety and depression in Chinese patients with cystic fibrosis (CF). Methods Clinical data from 28 CF patients in the cystic fibrosis registry study of Peking Union Medical College Hospital were collected and analyzed. Hospital anxiety and depression scale was used to identify anxiety and depression. Results The cohort had 42.9% (12/28) males with a mean age of 23±4.8 years. 14 patients (50%) had anxiety or depression. Among them, 8 subjects (28.6%) had moderate and severe anxiety or depression, and 5 patients (17.9%) were with moderate and severe anxiety, and 7 patients(25%) with moderate and severe depression. One patient(3.6%) had severe anxiety, no patients with severe depression, and four patients (14.3%) had both moderate and severe anxiety and depression. Compared to patients without anxiety or depression, patients with anxiety had significantly lower FVC% pred (54.5%±18.8% with anxiety, 80.0%±14.6% without anxiety or depression, P＜0.05), and patients with depression had significantly lower FEV₁% pred (41.6%±21.6% with depression, 64.2%±20.9% without anxiety or depression, P＜0.05) and FVC% pred (53.9%±21.0% with depression, 80.0%±14.6% without anxiety or depression, P＜0.01). Conclusions Half of CF patients have anxiety or depression, with a high comorbidity rate of anxiety and depression and a low prevalence of severe anxiety or depression in our cohort. CF patients with anxiety or depression have worse pulmonary ventilationy function compared to CF patients without anxiety or depression.

Key words: anxiety, depression, hospital anxiety and depression scale, cystic fibrosis