Abstract: Objective To explore the mediating effect of hope level in the depression and psychological resilience of patients with advanced lung cancer, in order to provide a theoretical basis for interventions to improve the depression state of patients. Methods Across-sectional survey was conducted in 202 patients with advanced lung cancer who were admitted to the Department of Respiratory Medicine of PUMCH from October 2019 to December 2020, using the Herth Hope Scale, Connor-Davidson resilience scale (CD-RISC) and a self-designed questionnaire on patient general condition and disease characteristics. Results The depression level of patients with advanced lung cancer was negatively correlated with the psychological resilience of the patients (r=-0.50, P＜0.01). The hope level of the patients was positively correlated with the psychological resilience (r=0.62, P＜0.01). The depression level of the patients was negatively correlated with the hope level(r=-0.44, P＜0.01).The level of hope of patients with advanced lung cancer has a partial mediating effect in depression and mental resilience. The mediating effect value is -16.51 (95% CI=-0.20~-0.03), the ratio is 19.83%. Conclusions Patients with advanced lung cancer who receive regular treatment have a higher degree of depression, and the hope level play a role of the mediating effect between depression and mental toughness. Medical staff should improve the confidence and hope of patients with advanced lung cancer through intervention, and improve pessimism.

Key words: advanced lung cancer, depression, psychological resilience, hope level, mediating effect