Abstract: Objective To implement and evaluate an online hybrid teaching mode as “rain classroom—directed self-study—scientific research design—home experiment” in the cloud experimental course of medical biochemistry for international students. Methods Research design and home experiments were introduced through revised design of teaching contents to develop a new online hybrid teaching mode. A total of 105 international students majoring in clinical medicine (MBBS, 89 students) and dentistry (BDS, 16 students) were selected to join the online the teaching mode during COVID-19 pandemic. Results Compared with the traditional experimental class, the cloud hybrid teaching model effectively stimulated students' enthusiasm and encouraged their participation in experimental course. Students used the existing teaching and online resources to complete the self-study independently, built capacity of research logical thinking, research methodology and then initiated research design and home experiments. Conclusions The training of research design and home experiments can support online experiment teaching in order to cultivate students' innovative thinking and capacity building of experiment technology, and to improve the teaching effect of online biochemistry experiments.

Key words: medical biochemistry and molecular biology experiment, cloud classroom for experimental courses, scientific experiment design, home experiment