肠道菌群与代谢手术治疗肥胖及其相关代谢性疾病的研究进展

doi:10.16352/j.issn.1001-6325.2026.02.0288

基础医学与临床 ›› 2026, Vol. 46 ›› Issue (2): 288-292.doi: 10.16352/j.issn.1001-6325.2026.02.0288

肠道菌群与代谢手术治疗肥胖及其相关代谢性疾病的研究进展

周健, 袁野^*

武汉科技大学附属武汉亚心总医院普外科,湖北武汉 430032

收稿日期:2025-03-12 修回日期:2025-05-27 出版日期:2026-02-05 发布日期:2026-01-21
通讯作者: ^* 93651434@qq.com
基金资助:
武汉市医学科研项目(WX21Q44)

Research progress on gut microbiota and metabolic surgery for the treatment of obesity and related metabolic diseases

ZHOU Jian, YUAN Ye^*

Department of General Surgery, Wuhan Asia General Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430042, China

Received:2025-03-12 Revised:2025-05-27 Online:2026-02-05 Published:2026-01-21
Contact: ^* 93651434@qq.com

摘要/Abstract

摘要： 肥胖及其相关代谢性疾病已成为全球重大健康挑战,传统疗法常存在疗效有限及易复发的缺陷。近年来,代谢手术作为治疗肥胖及其相关代谢疾病的重要手段,不仅能够显著减轻体质量,还在改善血糖水平、脂质代谢和降低心血管风险等方面表现出独特的疗效。代谢手术亦可改变肠道菌群的结构和功能,通过修复肠屏障功能、减少内毒素易位、抑制慢性炎性反应及调节代谢激素分泌,改善胰岛素敏感性和能量代谢平衡,在改善宿主代谢状态中起到关键作用。因此,本文对近年来关于肠道菌群与代谢手术在肥胖及其相关代谢性疾病中的研究进行综述,以期为开发新治疗策略提供思路。

关键词: 肠道菌群, 肥胖, 代谢手术, 代谢性疾病

Abstract: Obesity and its associated metabolic diseases have become significant global health challenges, with conventional therapies often limited by insufficient efficacy and high relapse rates. In recent years, metabolic surgery has emerged as a critical intervention for treating obesity and related metabolic disorders. Beyond achieving substantial weight loss, it demonstrates unique therapeutic benefits, including improvements in blood glucose levels, lipid metabolism, and reduced cardiovascular risk. Notably, metabolic surgery also alters the structure and function of the gut microbiota. These changes enhance host metabolic health by restoring intestinal barrier integrity, reducing endotoxin translocation, suppressing chronic inflammatory response, and regulating the secretion of metabolic hormones, thereby improving insulin sensitivity and energy homeostasis. Therefore, this paper provides a review of recent studies on the relationship between the intestinal microbiota and metabolic surgery in obesity and its related metabolic diseases, in order to provide new ideas for future treatment strategies.

Key words: gut microbiota, obesity, metabolic surgery, metabolic diseases

中图分类号:

R656.6

周健, 袁野. 肠道菌群与代谢手术治疗肥胖及其相关代谢性疾病的研究进展[J]. 基础医学与临床, 2026, 46(2): 288-292.

ZHOU Jian, YUAN Ye. Research progress on gut microbiota and metabolic surgery for the treatment of obesity and related metabolic diseases[J]. Basic & Clinical Medicine, 2026, 46(2): 288-292.

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肠道菌群与代谢手术治疗肥胖及其相关代谢性疾病的研究进展

Research progress on gut microbiota and metabolic surgery for the treatment of obesity and related metabolic diseases

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