巨噬细胞极化影响腰椎间盘退变的研究进展

doi:10.16352/j.issn.1001-6325.2025.09.1229

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (9): 1229-1233.doi: 10.16352/j.issn.1001-6325.2025.09.1229

巨噬细胞极化影响腰椎间盘退变的研究进展

陈旺, 李绪贵, 李瑛^*

湖北中医药大学针灸骨伤学院,湖北武汉 430065

收稿日期:2025-04-19 修回日期:2025-06-27 出版日期:2025-09-05 发布日期:2025-08-27
通讯作者: ^*995052246@qq.com
基金资助:
湖北省自然科学基金联合基金(2025AFD657);武汉附院博士专项(WTFY202402)

Research progress on macrophage polarization during the degeneration process of lumbar intervertebral discs

CHEN Wang, LI Xugui, LI Ying^*

College of Acupuncture and Bone Injury,Hubei University of Chinese Medicine,Wuhan 430065, China

Received:2025-04-19 Revised:2025-06-27 Online:2025-09-05 Published:2025-08-27
Contact: ^*995052246@qq.com

摘要/Abstract

摘要： 腰椎间盘退变(LIDD)的病理进程中,巨噬细胞极化通过M1/M2表型动态转换发挥关键调控作用。不同表型的巨噬细胞分布差异与疾病阶段及微环境密切相关,在加重椎间盘退变和促进椎间盘修复中发挥双重作用。巨噬细胞极化主要通过调节腰椎间盘炎性微环境、引发氧化应激(OS)、影响椎间盘细胞活性、调控椎间盘细胞外基质(ECM)降解等途径密切地影响LIDD过程。

关键词: 腰椎间盘退变, 巨噬细胞极化, 免疫微环境

Abstract: During pathological progression of lumbar intervertebral disc degeneration (LIDD), macrophage polarization functions as a critical regulatory mechanism through the dynamic transition between M1 and M2 phenotypes. The distribution of macrophages with distinct phenotypes is related to disease stages and the microenvironment, exerting dual effects by either exacerbating inter-vertebral disc degeneration or promoting its repair. Macrophage polarization significantly influences LIDD primarily by modulating the inflammatory microenvironment of the lumbar intervertebral disc, inducing oxidative stress (OS), altering intervertebral disc cell activity, and regulating the degradation of the intervertebral disc extracellular matrix (ECM).

Key words: lumbar intervertebral disc degeneration, macrophage polarization, immune microenvironment

中图分类号:

R681.5

陈旺, 李绪贵, 李瑛. 巨噬细胞极化影响腰椎间盘退变的研究进展[J]. 基础医学与临床, 2025, 45(9): 1229-1233.

CHEN Wang, LI Xugui, LI Ying. Research progress on macrophage polarization during the degeneration process of lumbar intervertebral discs[J]. Basic & Clinical Medicine, 2025, 45(9): 1229-1233.

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巨噬细胞极化影响腰椎间盘退变的研究进展

Research progress on macrophage polarization during the degeneration process of lumbar intervertebral discs

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