饮食、肠道菌群与血管钙化

doi:10.16352/j.issn.1001-6325.2025.02.0154

摘要/Abstract

摘要： 肠道菌群与肥胖、胰岛素抵抗、抑郁症、心血管风险密切相关,益生菌可以改善心血管疾病风险。血管钙化(VC)的过程受到严格调控,涉及矿物质沉积物在血管与瓣膜中的积累,是心血管疾病风险的危险因素。饮食对肠道菌群与血管钙化具有多重影响,可以通过菌群代谢产物影响心血管健康。尽管肠道菌群与血管钙化的关系已经得到证实,但饮食成分对血管钙化的确切影响尚不完全清楚。本文旨在综述不同饮食模式下肠道菌群与血管钙化之间的关系及其作用机制,为未来VC的诊断和治疗提供新的研究方向。

关键词: 肠道菌群, 血管钙化

Abstract: Gut microbiota, implicated in obesity, insulin resistance, depression, and cardiovascular risk, can be modulated by probiotics to mitigate cardiovascular disease risk. Vascular calcification (VC), a regulated process involving mineral deposits in vessels and valves, is a significant risk factor. Diet profoundly impacts both gut microbiota and VC, influencing cardiovascular health via microbial metabolites. While the link between gut microbiota and VC is established, the precise dietary effects on vascular health remain unclear. This article reviews mechanisms through which dietary patterns shape gut microbiota and metabolites, influence VC and highlights directions for future research on VC diagnosis and treatment.

Key words: gut microbiota, vascular calcification

中图分类号:

R541

刘怡铭, 陈文杰, 史雨晨, 柳景华. 饮食、肠道菌群与血管钙化[J]. 基础医学与临床, 2025, 45(2): 154-159.

LIU Yiming, CHEN Wenjie, SHI Yuchen, LIU Jinghua. Diet, gut microbiota and vascular calcification[J]. Basic & Clinical Medicine, 2025, 45(2): 154-159.

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