脑衰反应调节蛋白在视神经损伤中的作用

doi:10.16352/j.issn.1001-6325.2025.01.0102

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (1): 102-106.doi: 10.16352/j.issn.1001-6325.2025.01.0102

脑衰反应调节蛋白在视神经损伤中的作用

朱裕椿¹, 席鑫源¹, 杨珍¹, 冯东福^1,2*

1.上海交通大学附属第六人民医院南院神经外科,上海 201499;
2.上海交通大学医学院创伤医学研究所,上海 201999

收稿日期:2024-05-06 修回日期:2024-07-03 出版日期:2025-01-05 发布日期:2024-12-25
通讯作者: ^*drneuro@163.com
基金资助:
国家自然科学基金(82271388);上海市自然科学基金(22ZR1452700)

Role of collapsin response mediator proteins in optic nerve injury

ZHU Yuchun¹, XI Xinyuan¹, YANG Zhen¹, FENG Dongfu^1,2*

1. Department of Neurosurgery, Shanghai Jiaotong University Affiliated Sixth People′s Hospital South Campus, Shanghai 201499;
2. Institute of Trauma Medicine, Shanghai Jiaotong University School of Medicine, Shanghai 201999, China

Received:2024-05-06 Revised:2024-07-03 Online:2025-01-05 Published:2024-12-25
Contact: ^*drneuro@163.com

摘要/Abstract

摘要： 脑衰反应调节蛋白(CRMPs),也被称为二氢嘧啶酶样蛋白,包含5个家族成员(CRMP1、CRMP2、CRMP3、CRMP4、CRMP5)。在中枢神经系统中,CRMPs主要参与神经元的分化迁移、突触可塑性和神经突的生长发育、导向延伸等多种生理过程。近期研究发现视神经损伤后,通过抑制或降低CRMPs的磷酸化可以影响视网膜神经节细胞(RGCs)的存活及其轴突再生,这可能会为未来视神经损伤治疗提供新的思路。

关键词: 脑衰反应调节蛋白, 视神经损伤, 视网膜神经节细胞, 轴突再生

Abstract: Collapsin response mediator proteins (CRMPs), also known as dihydropyrimidine-like proteins, contain five isoforms (CRMP1, CRMP2, CRMP3, CRMP4, CRMP5). In central nervous system, CRMPs are mainly involved in a variety of physiological processes such as neuronal differentiation and migration, synaptic plasticity, neurite growth and development and guiding extension. Recent studies have found that inhibiting or reducing the phosphorylation of CRMPs can affect the survival and axonal regeneration of retinal ganglion cells (RGCs) after optic nerve injury, which may provide new ideas for the treatment of optic nerve injury in the future.

Key words: collapsin response mediator proteins, optic nerve injury, retinal ganglion cell, axonal regeneration

中图分类号:

朱裕椿, 席鑫源, 杨珍, 冯东福. 脑衰反应调节蛋白在视神经损伤中的作用[J]. 基础医学与临床, 2025, 45(1): 102-106.

ZHU Yuchun, XI Xinyuan, YANG Zhen, FENG Dongfu. Role of collapsin response mediator proteins in optic nerve injury[J]. Basic & Clinical Medicine, 2025, 45(1): 102-106.

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脑衰反应调节蛋白在视神经损伤中的作用

Role of collapsin response mediator proteins in optic nerve injury

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