microRNAs通过Hippo通路抑制肝细胞癌发生的研究进展

doi:10.16352/j.issn.1001-6325.2023.12.1871

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (12): 1871-1875.doi: 10.16352/j.issn.1001-6325.2023.12.1871

microRNAs通过Hippo通路抑制肝细胞癌发生的研究进展

查娜¹, 郝丹丹², 李天柱^3*

1.赤峰学院附属医院肿瘤内科,内蒙古赤峰 024000;
赤峰学院基础医学院 2.生理学教研室;
3.分子医学研究中心, 内蒙古赤峰 024000

收稿日期:2022-10-02 修回日期:2023-04-10 出版日期:2023-12-05 发布日期:2023-11-29
通讯作者: ^* litianzhu2016@163.com
基金资助:
国家自然科学基金(82060118);内蒙古自治区高等学校科学研究项目(NJZY20203);赤峰学院青年科技英才项目(CFXYYT2202);内蒙古自然科学基金 (2022MS08032)

Research progress of microRNAs suppressing tumorigenesis through Hippo signaling

CHA Na¹, HAO Dandan², LI Tianzhu^3*

1. Department of Oncology, the Affiliated Hospital of Chifeng University, Chifeng 024000;
2. Department of Physiology;
3. Molecular Medicine Research Center, School of Basic Medical Science, Chifeng University, Chifeng 024000, China

Received:2022-10-02 Revised:2023-04-10 Online:2023-12-05 Published:2023-11-29
Contact: ^* litianzhu2016@163.com

摘要/Abstract

摘要： Hippo信号通路下游效应器蛋白Yes相关蛋白(YAP)和转录辅助激活因子(TAZ)的异常激活参与肝细胞癌(HCC)恶性进展。微小RNA(miRNAs)作为抑癌基因通过Hippo YAP/TAZ信号影响HCC增殖、迁移和凋亡等途径调控HCC恶性生物学表型。探索miRNAs 调节Hippo YAP/TAZ通路在HCC中的作用可为诊断和治疗HCC提供新的思路。

关键词: 肝细胞癌, Hippo通路, 微小RNA, 分子机制

Abstract: The aberrant activation of yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), downstream effectors of the Hippo signaling pathway, has been implicated in hepatocellular carcinoma(HCC). The microRNAs (miRNAs) works as a tumor suppressors that influence the proliferation, migration and apoptosis of tumor cells by modulating Hippo-YAP/TAZ signaling during hepatic tumorigenesis. Exploring the role of miRNAs in regulating Hippo YAP/TAZ pathway in HCC can provide new ideas for the diagnosis and treatment of HCC.

Key words: hepatocellular carcinoma, Hippo pathway, microRNAs, molecular mechanism

中图分类号:

R735.7

查娜, 郝丹丹, 李天柱. microRNAs通过Hippo通路抑制肝细胞癌发生的研究进展[J]. 基础医学与临床, 2023, 43(12): 1871-1875.

CHA Na, HAO Dandan, LI Tianzhu. Research progress of microRNAs suppressing tumorigenesis through Hippo signaling[J]. Basic & Clinical Medicine, 2023, 43(12): 1871-1875.

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microRNAs通过Hippo通路抑制肝细胞癌发生的研究进展

Research progress of microRNAs suppressing tumorigenesis through Hippo signaling

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