线粒体功能障碍在肾结石成石中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.02.306

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (2): 306-310.doi: 10.16352/j.issn.1001-6325.2023.02.306

线粒体功能障碍在肾结石成石中作用的研究进展

何綦琪¹, 吴晃^1,2, 李昱卓¹, 包军胜^1*

1.兰州大学第二医院泌尿外科医学中心兰州大学第二医院泌尿外科研究所甘肃省泌尿系统疾病研究重点实验室,甘肃兰州 730030;
2.兰州大学第二临床医学院,甘肃兰州 730030

收稿日期:2021-11-18 修回日期:2022-04-07 出版日期:2023-02-05 发布日期:2023-02-02
通讯作者: ^*baojs@lzu.edu.cn
基金资助:
国家自然科学基金青年科学基金(81800671); 甘肃省卫生健康行业科研管理项目(GSWSKY2021-070);兰州大学萃英人才面上项目(CY2021-MS-A02);兰州市科学发展指导性计划项目(2022-ZD-105)

Research advance of mitochondrial dysfunction in the mechanism of renal stone formation

HE Qiqi¹, WU Huang^1,2, LI Yuzhuo¹, BAO Junsheng^1*

1. Department of Urology, Key Laboratory of Disease of Urological Systems, Gansu Nepho-Urological Clinical Center, Lanzhou University Second Hospital, Lanzhou 730030;
2. the Second Clinic Medicine College of Lanzhou University, Lanzhou 730030,China

Received:2021-11-18 Revised:2022-04-07 Online:2023-02-05 Published:2023-02-02
Contact: ^*baojs@lzu.edu.cn

摘要/Abstract

摘要： 肾结石成石过程与组织氧化应激及炎性反应具有显著相关性。线粒体是细胞内代谢的最重要的细胞器之一,其在供能、调节细胞氧化应激、维持钙稳态及细胞程序性死亡中具有关键作用。线粒体功能障碍会加速肾结石的成石进程,这可能与细胞抗氧化能力减弱、炎性通路激活、胞内钙及草酸稳态调节失衡等因素相关。明确线粒体功能障碍在肾结石成石过程中的潜在作用有利于加深对肾结石疾病的认知并促进其预防策略的革新。

关键词: 氧化应激, 钙稳态, 线粒体, 肾结石, 成石机制

Abstract: The relationship among oxidative stress, inflammations and stone formation has been proved. Mitochondria, as one of the most important organelles in cell, plays an important role in energy supply, oxidative stress, calcium homeostasis and cell programmed death. Mitochondrial dysfunction may accelerate the kidney stone-forming, which may be related to the decreased antioxidant capacity, the activation of inflammatory pathways, the imbalance of intracellular calcium and oxalic acid homeostasis. To clarify the roles of mitochondrial dysfunction in the formation of kidney stones may support the research on pathogenesis of the disease and to provide some potential novel ideas in the prophylactic study of renal stone in future.

Key words: oxidative stress, calcium homeostasis, mitochondria, renal stone, stone formation

中图分类号:

R692.4

何綦琪, 吴晃, 李昱卓, 包军胜. 线粒体功能障碍在肾结石成石中作用的研究进展[J]. 基础医学与临床, 2023, 43(2): 306-310.

HE Qiqi, WU Huang, LI Yuzhuo, BAO Junsheng. Research advance of mitochondrial dysfunction in the mechanism of renal stone formation[J]. Basic & Clinical Medicine, 2023, 43(2): 306-310.

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线粒体功能障碍在肾结石成石中作用的研究进展

Research advance of mitochondrial dysfunction in the mechanism of renal stone formation

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