复方倍他米松联合半导体激光治疗对糜烂型口腔扁平苔藓疗效以及念珠菌感染的影响

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (7): 965-970.

复方倍他米松联合半导体激光治疗对糜烂型口腔扁平苔藓疗效以及念珠菌感染的影响

王赛男¹, 任皓², 李新¹, 居云梦¹, 孔凡芝¹, 卢恕来^3*

1.青岛大学口腔医学院,山东青岛 266003;
2.滨州市人民医院口腔科,山东滨州 256600;
3.青岛市市立医院口腔医学中心,山东青岛 266011

收稿日期:2020-04-09 修回日期:2020-05-10 出版日期:2020-07-05 发布日期:2020-06-29
通讯作者: ^*lshl97@163.com
基金资助:
青岛市科技计划(17-3-3-39-nsh);青岛市优秀学科带头人项目(2019-2021)

Effect of compound betamethasone combined with semiconductor laser on erosive oral lichen planus and Candida

WANG Sai-nan¹, REN Hao², LI Xin¹, JU Yun-meng¹, KONG Fan-zhi¹, LU Shu-lai^3*

1. Stomatologial College, Qingdao University, Qingdao 266003;
2. Department of Stomatology, Binzhou People's Hospital, Binzhou 256600;
3. Stomatology Center, Qingdao Municipal Hospital, Qingdao 266011,China

Received:2020-04-09 Revised:2020-05-10 Online:2020-07-05 Published:2020-06-29
Contact: ^*lshl97@163.com

摘要/Abstract

摘要： 目的探讨复方倍他米松联合半导体激光治疗糜烂型口腔扁平苔藓(EOLP)的临床疗效及对念珠菌(Candida)感染的影响。方法选取在青岛市市立医院口腔黏膜科就诊的具有糜烂病损且病理确诊为EOLP的病例90例,随机分为A、B、C 3组,每组30例。A组患者采用复方倍他米松局麻下封闭治疗(1次/2周);B组患者采用半导体激光局部照射治疗(3次/周);C组患者采用复方倍他米松联合半导体激光治疗,3组疗程均为4周。分别在第2、4周观察记录每组患者病损面积和症状体征;分别采集治疗前及治疗后的唾液检测IL-17、IL-38的水平及白色念珠菌(C.albicans)的检出率,并对数据进行统计分析。结果治疗后,C组病损面积均小于A 组与B 组(P＜0.05); C组疼痛程度评分均低于A组和 B组(P＜0.05); C组症状体征评分均低于A组和B组(P＜0.05);治疗后,与A组相比B、C组患者白色念珠菌检出率下降(P＜0.05)。治疗后,与A、B组比较C组IL-17、IL-38有显著差异(P＜0.05)。结论复方倍他米松联合半导体激光治疗EOLP的总体效果优于单一方法治疗。

关键词: 糜烂型口腔扁平苔藓, 半导体激光, 复方倍他米松, 白色念珠菌

Abstract: Objective To investigate the clinical efficacy of compound betamethasone combined with semiconductor laser in the treatment of erosive oral lichen planus (EOLP). Methods Ninety cases with erosive lesions and pathologically confirmed EOLP diagnosed in the Department of Oral Mucosa of Qingdao Municipal Hospital were selected and randomly divided into three groups A, B, and C, with 30 cases in each and treated respectivel for 28 days. Group A patients were treated with compound betamethasone under local anesthesia (2 weeks/time); group B patients were treated with semiconductor laser local irradiation (3 times/week); group C patients were treated with betamethasone combined with semiconductor laser treatment.The lesion area and local focus were observed and recorded after 2 weeks and 4 weeks, Saliva were collected before and after treatment to detect the levels of IL-17 and IL-38, C.albicans were isolated with routine technology. Results After treatment, the lesion area of group C was significantly smaller than that of group A and group B(P＜0.05); the pain degree scores of group C were significantly lower than those of groups A and B(P＜0.05); the local focus scores of group C were significantly lower than those of groups A and B(P＜0.05). After treatment, the detection rate of C.albicans in group A, B and C patients was statistically significant(P＜0.05). After treatment, IL-17 and IL-38 in group C were significantly different from those in groups A and B(P＜0.05). Conclusions The overall effect of therapy with betamethasone plus semiconductor laser in the treatment of EOLP is better than that either mono-thearpy.

Key words: erosive oral lichen planus, semiconductor laser, compound betamethasone, Candida albicans

中图分类号:

R781.4

王赛男, 任皓, 李新, 居云梦, 孔凡芝, 卢恕来. 复方倍他米松联合半导体激光治疗对糜烂型口腔扁平苔藓疗效以及念珠菌感染的影响[J]. 基础医学与临床, 2020, 40(7): 965-970.

WANG Sai-nan, REN Hao, LI Xin, JU Yun-meng, KONG Fan-zhi, LU Shu-lai. Effect of compound betamethasone combined with semiconductor laser on erosive oral lichen planus and Candida[J]. Basic & Clinical Medicine, 2020, 40(7): 965-970.

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