基础医学与临床 ›› 2018, Vol. 38 ›› Issue (2): 246-250.

• 短篇综述 • 上一篇    下一篇

靶向肿瘤干细胞的免疫疗法

江伦1,白丽2   

  1. 1. 大理大学
    2. 大理学院基础医学院
  • 收稿日期:2016-12-30 修回日期:2017-04-24 出版日期:2018-02-05 发布日期:2018-01-24
  • 通讯作者: 白丽 E-mail:lbai@dali.edu.cn
  • 基金资助:
    国家自然科学基金资助项目(81360319);云南省科技厅重点项目(2014FA007)

Immunotherapy of targeting at tumor stem cells

  • Received:2016-12-30 Revised:2017-04-24 Online:2018-02-05 Published:2018-01-24
  • Supported by:
    Project supported by the National Natural Science Foundation of China(NO. 81360319);the Key Project of Science and Technology Department of Yunnan(NO.2014FA007)

摘要: 由于肿瘤干细胞(TSCs)与肿瘤的发生﹑发展﹑转移﹑复发和耐药等有着密切关系,是肿瘤的根源细胞,意味着治愈肿瘤的关键途径可能在于根除TSCs。因传统的手术﹑化疗和放疗等对肿瘤治疗的方法无法杀死TSCs,容易导致肿瘤转移和复发,而靶向TSCs的免疫疗法已确定能杀伤TSCs,如靶向TSCs的表面抗原﹑T细胞靶向TSCs的应用和分化疗法等。

关键词: 肿瘤, 肿瘤干细胞, 免疫疗法

Abstract: Tumor stem cells (TSCs), because of its close relations to occurrence, development, metastasis, recurrence and drug resistance of tumor, is considered by research commnity as root cause of the tumor cells. In other words, The key way to cure tumor may be to eradicate TSCs. The traditional surgery, chemotherapy and radiotherapy not only have rare effect in killing TSCs, but also result in recurrence and metastasis easily. However, TSCs can definitely killed by the immunotherapy targeting TSCs, for instance, targeting the surface antigens of TSCs’, T cells targeting the TSCs, differentiation therapy and so on.

Key words: tumor, tumor stem cells, immunotherapy