关键词: 关键词：特纳综合征, 肝功能, 年龄, 体质量指数, 染色体核型

Abstract: Objective To investigate the incidence of abnormal liver function and the affecting factors in Turner syndrome (TS). Methods Forty-four TS patients aged 13.6±5.0 years old were recruited from the Department of Endocrinology, Peking Union Medical College Hospital during March 2010 to July 2015. And 120 girls aged 13.2±0.7 years old were selected as normal controls. Height, weight and liver function tests including alanine transaminase (ALT) and total bilirubin were measured in all 164 participants. All 44 TS patients were confirmed with chromosome karyotypes. Results The incidence of abnormal liver function in TS patients was 18.2%, mainly manifested as ALT elevation, while the incidence of abnormal liver function in control group was 3.3%. There were no significant differences in age, BMI and karyotypes among TS patients with or without ALT abnormality. Conclusions The incidence of abnormal liver function is higher in TS patients. Regular liver function tests should be performed in these patients. And the diagnosis of TS should be considered when abnormal liver function was noted in female patients with short stature.

Key words: Key words:Turner syndrome, Liver function, Age, BMI, Karyotypes