关键词: 关键词：miR-760, 胃癌, 增殖, 迁移, 侵袭

Abstract: Objective To investigate the effects of miR-760 on cell proliferation, migration and invasion of gastric cancer cell line MGC-803. Methods The level of miR-760 expression was detected by real-time RT-PCR in 50 paired gastric cancer tissues and their adjacent normal tissues. miR-760 overexpression was achieved by transfection of construct pcDNA-miR-760 into MGC-803 cells. The proliferation, migration and invasion of MGC-803 cells were detected by the CCK-8, Transwell and scratch wound assay, respectively. Results miR-760 was decreased in 36 cases (72%) of gastric cancer tissues compared to their control. Furthermore, overexpression of miR-760 effectively inhibited the migration and invasion of MGC-803 cells（p<0.05）, but had no effects on proliferation. Conclusion Down-regulation of miR-760 has a correlation with the progression of gastric cancer. Up-regulation of miR-760 can inhibit the invasion and migration of MGC-803 cells.

Key words: Key words：miR-760, gastric cancer, proliferation, migration, invasion