关键词: 血管紧张素转化酶, 血管紧张素酶原, 高血压, 脑梗塞, 基因多态性

Abstract: Objective To explore the association between the ACE, AGT gene polymorphism and hypertension disease complicated with cerebral infraction．Methods The ACE gene I/D polymorphism and the AGT gene M235T polymorphism were detected in a study of 664 cerebral infraction (CI) cases, 678simple essential hypertension (EH) cases and 716 control cases (C). The association of gene polymorphism and hypertension disease complicated with cerebral infraction is evaluated. Results The genotype frequencies of ACE-DD and AGT-TT in the CI group (0.309 and 0.643) were significantly higher than those in the control group (0.203 and 0.543) and EH group (0.217 and 0.569), respectively. The OR value of combining ACE-DD and AGT-TT of CI to the control group (2.547，95%CI : 1.919~3.382) is significantly higher than the OR value of single ACE-DD genotype (1.759，95%CI : 1.376~2.248) or single AGT-TT genotype（1.515, 95%CI : 1.220~1.880). Conclusions These results suggest that ACE-DD or AGT-TT variant is not associated with Chinese hypertensive patients, but is significantly associated with Chinese hypertensive patients complicated with cerebral infraction. ACE-DD and AGT-TT may have a synergistic effect on risk of hypertension disease complicated with cerebral infraction.

Key words: angiotensin-converting enzyme, angiotensinogen, hypertension, cerebral infraction, gene polymorphism