基础医学与临床 ›› 2011, Vol. 31 ›› Issue (8): 955-958.

• 短篇综述 • 上一篇    

肾细胞癌关键基因的研究进展

王清海1,石冰冰2   

  1. 1. 中国医学科学院 北京协和医学院 北京协和医院 泌尿外科
    2. 中国医学科学院 北京协和医学院 北京协和医院
  • 收稿日期:2011-03-22 修回日期:2011-04-28 出版日期:2011-08-05 发布日期:2011-07-13
  • 通讯作者: 王清海 E-mail:495158203@qq.com

Progress of key genes involved in renal cell carcinoma

Qing-hai WANG1,Bing-bing SHI2   

  1. 1. Dept.of Urology,PUMC Hospital,CAMS & PUMC
    2. PUMC Hospital,CAMS & PUMC
  • Received:2011-03-22 Revised:2011-04-28 Online:2011-08-05 Published:2011-07-13
  • Contact: Qing-hai WANG E-mail:495158203@qq.com

摘要: 肾细胞癌是一类多基因相关的肿瘤,不同组织学类型的肾癌有不同的基因改变,它们的临床特征,对治疗的反应也不尽相同。因此,对肾癌相关基因的研究不仅加深了人们对肾癌发病机制的了解,而且具有重要的临床意义。本文总结了VHL、PBRM1、MET、FH 及BHD等肾癌关键基因,分析其在肾癌诊断治疗方面的价值。

关键词: 肾细胞癌, 基因

Abstract: Renal cell carcinoma is a type of multi-gene-related cancer, different subtype with a different histology, having a different clinical characteristics, responding differently to therapy and caused by different genes. Therefore, studying the related genes of cancer of the kidney has significant implications not only in depth understanding of the pathogenesis of renal cell carcinoma, but also in clinical application. This article reviews the major involved kidney cancer genes,such as VHL, PBRM1, MET, FH, BHD, etc., and analyzes their value in diagnosis and treatment of renal cell carcinoma.

Key words: renal cell carcinoma, genes

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