关键词: STK15, 基因多态, 结直肠癌, meta-分析, 易感性

Abstract: Objective To determine whether STK15 Phe31Ile Polymorphism contributes to genetic susceptibility to colorectal cancer, through summarizing the results of published works in this field by a meta-analysis. Methods Pubmed、EMbase、SCI、Web of Science、CNKI、VIP and some other databases were searched for literatures published from January 2000 to April 2010. Articles were identified using the Medical Subject Headings term “STK15”、“polymorphism”、 “aurora-A”、“colorectal cancer”、“colorectal carcinoma”. Case control studies involving unrelated subjects and genotype frequencies in control group consistent with Hardy-Weinberg equilibrium were included. The software Stata(Version10.0) was used for meta-analysis. Results Six studies including 5158 patients and 4608 controls met the selection criteria. The combined OR of susceptibility to colorectal cancer with Phe/Ile and Ile/Ile compared to Phe/Phe were 1.01(95%CI: 0.93~1.10) and 1.18 (95%CI: 0.98~ 1.42); and their responding P values were 0.81and 0.081 respectively. Conclusion The findings suggest STK15 Phe31Ile Polymorphism is not correlated with susceptibility to colorectal cancer. Further study is needed to confirm STK15 Phe31Ile polymorphism and susceptibility to colorectal cancer in Chinese population.