维生素D在防治结直肠癌及补充应用的研究进展

doi:10.16352/j.issn.1001-6325.2025.03.0404

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (3): 404-408.doi: 10.16352/j.issn.1001-6325.2025.03.0404

维生素D在防治结直肠癌及补充应用的研究进展

张树军¹, 栗甜甜³, 钟明亮¹, 张剑^2*, 董欣敏^3*

1.内蒙古医科大学第一临床医学院放射肿瘤学系,内蒙古呼和浩特 010000;
2.内蒙古医科大学附属医院放射治疗科,内蒙古呼和浩特 010000;
3.内蒙古医科大学附属人民医院肿瘤科,内蒙古呼和浩特 010000

收稿日期:2024-07-22 修回日期:2024-10-30 发布日期:2025-02-25
通讯作者: ^*zhangjian3158@126.com;dongmin3158@126.com
基金资助:
内蒙古医科大学博士启动基金(NYFY BS 202136);内蒙古医科大学实验室开放基金(2023ZN12)

Progress on vitamin D in the preventionand treatment of colorectal cancer and its supplementation applications

ZHANG Shujun¹, LI Tiantian³, ZHONG Mingliang¹, ZHANG Jian^2*, DONG Xinmin^3*

1. Department of Radiation Oncology, the First School of Clinical Medicine, Inner Mongolia Medical University, Hohhot 010000;
2. Department of Radiotherapy, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010000;
3. Department of Oncology, the Affiliated People′s Hospital of Inner Mongolia Medical University, Hohhot 010000, China

Received:2024-07-22 Revised:2024-10-30 Published:2025-02-25

摘要/Abstract

摘要： 结直肠癌是消化系统常见的恶性肿瘤之一,在中国其发病率和病死率逐年上升,严重威胁着人群的生命和健康。维生素D可以通过抑制肿瘤细胞增殖,促进肿瘤细胞凋亡,抑制肿瘤细胞迁移、侵袭和血管生成,增强机体免疫系统在抑制结直肠癌发挥重要作用。本文总结分析维生素D在抑制结直肠癌发生发展的具体作用机制,并阐述目前维生素D补充应用研究进展为维生素D在结直肠癌早期预防和辅助治疗等方面提供新的参考。

关键词: 维生素D, 结直肠癌, 维生素D剂量

Abstract: Colorectal cancer is one of the common malignant tumors in digestive system, because of its incidence and mortality rates rising annually in China, seriously threating to people′s lives and health. Vitamin D plays an important role in inhibiting colorectal cancer by suppressing tumor cell proliferation, promoting tumor cell apoptosis, inhibiting tumor cell migration, invasion, and angiogenesis and also, enhancing the body′s immune system. This article summarizes and analyzes the specific mechanisms by which vitamin D inhibits the occurrence and development of colorectal cancer, and discusses the current progress in research on vitamin D supplementation, providing new references for the early prevention and adjuvant treatment of colorectal cancer.

Key words: vitamin D, colorectal cancer, dosage of vitamin D

中图分类号:

R453.3

张树军, 栗甜甜, 钟明亮, 张剑, 董欣敏. 维生素D在防治结直肠癌及补充应用的研究进展[J]. 基础医学与临床, 2025, 45(3): 404-408.

ZHANG Shujun, LI Tiantian, ZHONG Mingliang, ZHANG Jian, DONG Xinmin. Progress on vitamin D in the preventionand treatment of colorectal cancer and its supplementation applications[J]. Basic & Clinical Medicine, 2025, 45(3): 404-408.

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维生素D在防治结直肠癌及补充应用的研究进展

Progress on vitamin D in the preventionand treatment of colorectal cancer and its supplementation applications

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