巨噬细胞胞外诱捕网在感染性疾病中的作用

doi:10.16352/j.issn.1001-6325.2026.03.0450

基础医学与临床 ›› 2026, Vol. 46 ›› Issue (3): 450-455.doi: 10.16352/j.issn.1001-6325.2026.03.0450

巨噬细胞胞外诱捕网在感染性疾病中的作用

袁佳敏, 方成超, 江君生^*

浙江大学第二附属医院临平院区儿科,浙江杭州 310000

收稿日期:2025-06-03 修回日期:2025-10-30 出版日期:2026-03-05 发布日期:2026-02-25
通讯作者: ^*18119600365@163.com
基金资助:
浙江省医药卫生科技项目(2024KY1463,2025KY1223);杭州市临平区科技计划(LPWJ2024-D2-33)

Role of macrophage extracellular traps in infectious diseases

YUAN Jiamin, FANG Chengchao, JIANG Junsheng^*

Department of Pediatrics,Linping branch, the Second Affiliated Hospital of Zhejiang University,Hangzhou 310000, China

Received:2025-06-03 Revised:2025-10-30 Online:2026-03-05 Published:2026-02-25
Contact: ^*18119600365@163.com

摘要/Abstract

摘要： 巨噬细胞胞外诱捕网(METs)是近年来发现的一种新型免疫防御机制,与中性粒细胞胞外诱捕网(NETs)类似,但其在感染性疾病中的作用尚未完全阐明。METs通过释放DNA、组蛋白和抗菌蛋白等成分参与宿主防御,但其过度或异常激活可能加剧炎性反应,导致组织损伤。本文综述了METs的生物学特性、激活途径、及其在各系统感染性疾病中的潜在作用机制,并探讨了靶向METs的治疗策略,如抑制METs形成或促进其清除,以减轻炎性反应,旨在为感染性疾病的治疗提供新的理论依据和潜在治疗靶点。

关键词: 巨噬细胞胞外诱捕网(METs), 感染性疾病, 免疫防御, 治疗策略

Abstract: Macrophage extracellular traps (METs) are newly discovered mechanism of immune system. Like neutrophil extracellular traps (NETs), their role in infectious diseases has not been fully elucidated. METs participate in host defense by releasing components such as DNA, histones, and antimicrobial proteins; However, their excessive or abnormal activation may exacerbate inflammatory responses and cause tissue damage. This article reviews the biological characteristics of METs, their activation pathways, and their potential mechanism of action in infectious diseases of various systems. It also explores METs- targeted therapeutic strategies, such as inhibiting METs formation or promoting their clearance to alleviate inflammatory responses, aiming to provide new theoretical basis and potential therapeutic targets for the treatment of infectious diseases.

Key words: macrophage extracellular traps(METs), infectious disease, immune defense, therapeutic strategies

中图分类号:

R364.7

袁佳敏, 方成超, 江君生. 巨噬细胞胞外诱捕网在感染性疾病中的作用[J]. 基础医学与临床, 2026, 46(3): 450-455.

YUAN Jiamin, FANG Chengchao, JIANG Junsheng. Role of macrophage extracellular traps in infectious diseases[J]. Basic & Clinical Medicine, 2026, 46(3): 450-455.

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巨噬细胞胞外诱捕网在感染性疾病中的作用

Role of macrophage extracellular traps in infectious diseases

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