Isthmin-1对糖脂代谢的调控作用及其临床意义

doi:10.16352/j.issn.1001-6325.2026.03.0445

基础医学与临床 ›› 2026, Vol. 46 ›› Issue (3): 445-449.doi: 10.16352/j.issn.1001-6325.2026.03.0445

Isthmin-1对糖脂代谢的调控作用及其临床意义

何萍, 王艳^*

川北医学院附属医院内分泌科,四川南充 637000

收稿日期:2025-05-06 修回日期:2025-06-23 出版日期:2026-03-05 发布日期:2026-02-25
通讯作者: ^*245369159@qq.com
基金资助:
四川省基层卫生事业发展研究中心2024年项目(SWFZ24-Y-69)

Regulatory role of isthmin-1 in glucose and lipid metabolism and its clinical implications

HE Ping, WANG Yan^*

Department of Endocrinology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

Received:2025-05-06 Revised:2025-06-23 Online:2026-03-05 Published:2026-02-25
Contact: ^*245369159@qq.com

摘要/Abstract

摘要： Isthmin-1(ISM1)是一种新型脂肪因子,通过组织特异性方式调控糖脂代谢:在骨骼肌和脂肪组织中,ISM1激活非胰岛素依赖的mTORC2/PI3K/AKT信号通路,促进GLUT4膜转位,增强葡萄糖摄取并改善胰岛素敏感性;在肝脏中,ISM1则抑制甾醇调节元件结合蛋白-1(Srebp1c)转录活性及其下游脂质合成基因表达,减少脂质新生。然而,ISM1在脂肪微环境中具有促炎潜力,可能加剧局部炎性反应与纤维化。ISM1独特的组织特异性调控机制,使其成为开发针对代谢性疾病个体化精准治疗策略的潜在新靶点。

关键词: isthmin-1, 脂肪因子, 糖脂代谢, 胰岛素抵抗, 代谢炎性反应

Abstract: Isthmin-1 (ISM1), a novel adipokine, regulates glucose and lipid metabolism with a tissue-specific manner. In skeletal muscle and adipose tissue, ISM1 activates the insulin-independent mTORC2/PI3K/AKT signaling pathway, promoting GLUT4 translocation to the membrane, enhancing glucose uptake, and improving insulin sensitivity. In the liver, ISM1 suppresses the transcriptional activity of sterol regulatory element binding protein-1(Srebp1c) and the expression of downstream lipid synthesis genes, thereby reducing de novo lipogenesis. However, ISM1 exhibits pro-inflammatory potential in the adipose microenvironment, which may contribute to local inflammation and fibrosis. These tissue-specific regulatory effects highlight ISM1′s potential as a novel target for developing individualized, precision therapies for metabolic diseases.

Key words: isthmin-1, adipokine, glucose and lipid metabolism, insulin resistance, metabolic inflammation

中图分类号:

R589

何萍, 王艳. Isthmin-1对糖脂代谢的调控作用及其临床意义[J]. 基础医学与临床, 2026, 46(3): 445-449.

HE Ping, WANG Yan. Regulatory role of isthmin-1 in glucose and lipid metabolism and its clinical implications[J]. Basic & Clinical Medicine, 2026, 46(3): 445-449.

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Isthmin-1对糖脂代谢的调控作用及其临床意义

Regulatory role of isthmin-1 in glucose and lipid metabolism and its clinical implications

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