直肠癌组织中KIF23的表达与预后相关

doi:10.16352/j.issn.1001-6325.2025.08.1054

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (8): 1054-1058.doi: 10.16352/j.issn.1001-6325.2025.08.1054

直肠癌组织中KIF23的表达与预后相关

吴海丰¹, 李小龙¹, 李芳², 陈晓华¹, 宋瑞¹, 韩雪^3*

保定市第一中心医院 1.普通外一科;2.烧伤整形外科,河北保定 071000;
3.河北省皮肤病防治院外科,河北保定 071000

收稿日期:2025-01-10 修回日期:2025-04-28 出版日期:2025-08-05 发布日期:2025-07-11
通讯作者: ^*hanxuehanxue623@163.com
基金资助:
保定市科技计划项目(2241ZF063)

Expression of KIF23 in rectal cancer tissues is correlated with prognosis

WU Haifeng¹, LI Xiaolong¹, LI Fang², CHEN Xiaohua¹, SONG Rui¹, HAN Xue^3*

1. Department of General Surgery 1; 2. Department of Burn Plastic Surgery, Baoding First Central Hospital, Baoding 071000;
3. Department of Surgery, Hebei Provincial Institute of Dermatology Prevention and Treatment, Baoding 071000, China

Received:2025-01-10 Revised:2025-04-28 Online:2025-08-05 Published:2025-07-11
Contact: ^*hanxuehanxue623@163.com

摘要/Abstract

摘要： 目的探讨驱动蛋白家族成员23(KIF23)在直肠癌中的表达及其与预后的关联。方法选取2017年5月至2019年10月在保定市第一中心医院接受手术治疗的90例直肠癌患者作为研究对象。免疫组化染色检测KIF23表达,并结合临床病理资料进行分析。使用Kaplan-Meier生存曲线和Cox回归分析评估KIF23表达与预后的关系。结果与癌旁组织比较,直肠癌组织中KIF23蛋白的表达水平显著升高。 KIF23的阳性表达与直肠癌的TNM分期、淋巴结转移状态以及远处转移情况之间存在显著的相关性(P＜0.05)。Kaplan-Meier生存分析结果显示,KIF23高表达患者的无病生存期 (DFS)和总生存期(OS)均显著低于KIF23低表达的患者(均P＜0.05)。Cox回归分析结果显示,TNM分期高、淋巴结转移、远处转移以及KIF23高表达是直肠癌患者预后不良的独立危险因素(P＜0.05)。结论 KIF23的表达水平与直肠癌的预后密切相关。

关键词: 驱动蛋白家族成员23, 直肠癌, 预后

Abstract: Objective To investigate the expression of kinesin family member 23 (KIF23) in rectal cancer and its association with prognosis. Methods This study included 90 patients with rectal cancer who underwent surgical treatment at the First Central Hospital of Baoding from May 2017 to October 2019. Immunohistochemical staining was used to detect KIF23 expression, and the results were analyzed in combination with clinical and pathological data. Survival analysis was conducted using Kaplan-Meier methods and Cox proportional hazards models to assess the association between KIF23 expression and patient prognosis. Results Compared with adjacent non-tumor tissues, the expression level of KIF23 protein was significantly higher in rectal cancer tissues. Positive expression of KIF23 was significantly correlated with TNM stage, lymph node metastasis and distant metastasis in rectal cancer patients (P＜0.05). Kaplan-Meier analysis revealed that individuals expressing high levels of KIF23 experienced notably diminished disease-free survival (DFS) and overall survival (OS) relative to those with low KIF23 expression(P＜0.05). Cox regression analysis revealed that advanced TNM stage, lymph node metastasis, distant metastasis, and elevated KIF23 expression served as an independent predictor of adverse outcomes in patients with rectal cancer (P＜0.05). Conclusions The expression level of KIF23 is closely related to the prognosis of rectal cancer.

Key words: kinesin family member 23, rectal cancer, prognosis

中图分类号:

吴海丰, 李小龙, 李芳, 陈晓华, 宋瑞, 韩雪. 直肠癌组织中KIF23的表达与预后相关[J]. 基础医学与临床, 2025, 45(8): 1054-1058.

WU Haifeng, LI Xiaolong, LI Fang, CHEN Xiaohua, SONG Rui, HAN Xue. Expression of KIF23 in rectal cancer tissues is correlated with prognosis[J]. Basic & Clinical Medicine, 2025, 45(8): 1054-1058.

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直肠癌组织中KIF23的表达与预后相关

Expression of KIF23 in rectal cancer tissues is correlated with prognosis

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