儿童肥胖与疾病的研究进展

doi:10.16352/j.issn.1001-6325.2025.11.1491

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (11): 1491-1495.doi: 10.16352/j.issn.1001-6325.2025.11.1491

儿童肥胖与疾病的研究进展

孙晓平, 陈敏^*

川北医学院附属医院内分泌科,四川南充 637000

收稿日期:2025-06-13 修回日期:2025-09-16 出版日期:2025-11-05 发布日期:2025-10-24
通讯作者: ^*chenmin1972@sina.com

Research progress on childhood obesity and diseases

SUN Xiaoping, CHEN Min^*

Department of Endocrinology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

Received:2025-06-13 Revised:2025-09-16 Online:2025-11-05 Published:2025-10-24
Contact: ^*chenmin1972@sina.com

摘要/Abstract

摘要： 儿童肥胖不仅会导致多种慢病的患病风险增加,还可能影响儿童的智力水平及执行功能,甚至出现精神心理问题。儿童肥胖对健康的影响可延续至成年期,引发一系列肥胖相关并发症,如2型糖尿病、血脂异常、代谢功能障碍相关脂肪性肝病、高血压、心力衰竭、心肌病、阻塞性睡眠呼吸暂停、哮喘、性早熟及性腺功能减退等。重视儿童肥胖问题,早期识别并进行相关干预,有望降低肥胖造成的危害。

关键词: 儿童肥胖, 并发症, 发病机制

Abstract: Obesity during childhood not only increases the risk of various chronic diseases, but also may affect a child's intelligence level and executive function, and even lead to mental and psychological problems. The impact of childhood obesity on health can persist into adulthood, leading to a series of obesity-related complications, such as type 2 diabetes, dyslipidemia, metabolic dysfunction-associated steatotic liver disease, hypertension, heart failure, cardiomyopathy, obstructive sleep apnea, asthma, precocious puberty, and hypogonadism. Paying attention to the issue of childhood obesity, early identification and relevant intervention are expected to reduce the harm caused by obesity.

Key words: childhood obesity, complication, pathogenesis

中图分类号:

R589.2

孙晓平, 陈敏. 儿童肥胖与疾病的研究进展[J]. 基础医学与临床, 2025, 45(11): 1491-1495.

SUN Xiaoping, CHEN Min. Research progress on childhood obesity and diseases[J]. Basic & Clinical Medicine, 2025, 45(11): 1491-1495.

参考文献 24

[1]	Fraiman J, Baver S, Henneberg M. Microevolutionary hypothesis of the obesity epidemic[J]. PLoS One, 2024, 19:e305255.doi: 10.1371/journal.pone.0305255.
[2]	Tisano B, Anigian K, Kantorek N, et al. The insidious effects of childhood obesity on orthopedic injuries and deformities[J]. Orthop Clin North Am, 2022, 53:461-472.
[3]	Sui Y, Cui L, Jia B, et al. Correlation between gross motor coordination and basic coordination capacities in normal-weight and overweight/obese children aged 9–10 years[J]. PeerJ, 2024, 12:e17865.doi: 10.7717/peerj.17865.
[4]	Smyczynska J, Olejniczak A, Rozycka P, et al. Obesity-related complications including dysglycemia based on 1-h post-load plasma glucose in children and adolescents screened before and after COVID-19 pandemic[J]. Nutrients, 2024, 16:2568.doi: 10.3390/nu16152568.
[5]	Sinha S, Das S, Vinayagamoorthy V, et al. Dyslipidemia among overweight and obese children in Jharkhand: a hospital-based study[J]. Indian Pediatr, 2023, 60:641-643.
[6]	Staníková D, Krajcˇovicˇová L, Demková L, et al. Food preferences and thyroid hormones in children and adolescents with obesity[J]. Front Psychiatry, 2022, 13:962949.doi: 10.3389/fpsyt.2022.962949.
[7]	Metwalley KA, Farghaly HS. Subclinical hypothyroidism in children: updates for pediatricians[J]. Ann Pediatr Endocrinol Metab, 2021, 26:80-85.
[8]	Rinella ME, Lazarus JV, Ratziu V, et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature[J]. Hepatology, 2023, 78:1966-1986.
[9]	Fan X, Wang Y, Wang Y, et al. Dapagliflozin attenuates metabolic dysfunction-associated steatotic liver disease by inhibiting lipid accumulation, inflammation and liver fibrosis[J]. BMC Pharmacol Toxicol, 2025, 26:59.doi: 10.1186/s40360-025-00898-z.
[10]	Ma Y, Wang L, Tao M, et al. Interaction between obesity and asthma in children and adolescents with hypertension based on NHANES 2007-2020[J]. Front Public Health, 2025, 13:1526832.doi: 10.3389/fpubh.2025.1526832.
[11]	Kong R, Li S. Effects of childhood obesity on heart failure and its associated risk factors in the European population: a Mendelian randomization study[J]. Nutr Metab Cardiovasc Dis, 2024, 34:1080-1087.
[12]	Andrades C, Poletti VV, Closs VE, et al. Prevalence of dyslipidemia, atherogenic and cardiovascular risk in overweight and obese adolescents[J]. Rev Paul Pediatr, 2023, 41:e2021312.doi: 10.1590/1984-0462/2023/41/2021312.
[13]	Robertson J, Schaufelberger M, Lindgren M, et al. Higher body mass index in adolescence predicts cardiomyopathy risk in midlife[J]. Circulation, 2019, 140:117-125.
[14]	丁佳韵, 张博雅, 戴一鸣, 等. 肥胖持续状态对学龄儿童肺功能的影响[J]. 中国学校卫生, 2024, 45:549-553.
[15]	Xiao L, Su S, Liang J, et al. Analysis of the risk factors associated with obstructive sleep apnea syndrome in Chinese children[J]. Front Pediatr, 2022, 10:900216.doi: 10.3389/fped.2022.900216.
[16]	Reyes-Angel J, Kaviany P, Rastogi D, et al. Obesity-related asthma in children and adolescents[J]. Lancet Child Adolesc Health, 2022, 6:713-724.
[17]	Zhang Y, Yuan X, Yang X, et al. Associations of obesity with growth and puberty in children: a cross-sectional study in Fuzhou, China[J]. Int J Public Health, 2023, 68:1605433.doi: 10.3389/ijph.2023.1605433.
[18]	Hassan MM, Sarry EA, Musa N, et al. Insights into the implication of obesity in hypogonadism among adolescent boys[J]. J Pediatr Endocrinol Metab, 2022, 35:1497-1504.
[19]	Herrera R, Lurbe E. A holistic perspective of the comorbidities in childhood obesity[J]. An Pediatr (Engl Ed), 2024, 101:344-350.
[20]	马冰洁, 卢少敏, 邢艳菲, 等. 超重肥胖儿童智力水平及执行功能的表现特征[J]. 中国儿童保健杂志, 2023, 31:601-605.
[21]	Haksever M, Durgut O, Demirci H, et al. Relationship between otitis media with effusions and pediatric obesity[J]. Int J Pediatr Otorhinolaryngol, 2022, 161:111272.doi: 10.1016/j.ijporl.2022.111272.
[22]	Leary SD, Ha DH, Dudding T, et al. Association between overweight/obesity and dental outcomes in early childhood: findings from an Australian cohort study[J]. Community Dent Oral Epidemiol, 2025, 53:50-57.
[23]	Hasse L, Jamiolkowski D, Reschke F, et al. Pediatric obesity and skin disease: cutaneous findings and associated quality-of-life impairments in 103 children and adolescents with obesity[J]. Endocr Connect, 2023, 12:e230235.doi: 10.1530/EC-23-0235.
[24]	国家卫生健康委员会肥胖症诊疗指南编写委员会. 肥胖症诊疗指南(2024年版)[J]. 中国循环杂志, 2025, 40:6-30.

儿童肥胖与疾病的研究进展

Research progress on childhood obesity and diseases

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 24

相关文章 15

编辑推荐

Metrics

本文评价

[1]	朱启海, 张俣. 低氧诱导因子-1α在肌肉减少症发病中作用机制[J]. 基础医学与临床, 2025, 45(8): 1093-1097.
[2]	艾英, 路盼, 牛晓丽. 新生儿坏死性小肠结肠炎术后肺部并发症危险因素分析[J]. 基础医学与临床, 2025, 45(3): 365-369.
[3]	杨若彤, 赵国英, 王浩. 新生儿急性肺损伤的发病机制[J]. 基础医学与临床, 2025, 45(1): 135-139.
[4]	苏凌峰, 王虎霞, 王延峰, 宋张骏. 慢性压力对乳腺癌发展的影响[J]. 基础医学与临床, 2024, 44(9): 1303-1307.
[5]	彭煜, 易杰. 全身麻醉手术中气管插管和喉罩通气道对术后肺部并发症的影响[J]. 基础医学与临床, 2024, 44(9): 1314-1319.
[6]	彭晴怡, 许岭翎. 1型糖尿病诱发肌少症的研究进展[J]. 基础医学与临床, 2024, 44(8): 1189-1193.
[7]	张毅, 申乐. 新型冠状病毒感染患者术后并发症及相关危险因素[J]. 基础医学与临床, 2024, 44(3): 408-411.
[8]	张雅慧, 白琼. 低氧诱导因子-1α在糖尿病肾病中作用机制的研究进展[J]. 基础医学与临床, 2024, 44(1): 114-118.
[9]	陈王跃, 薛芳, 韩伟, 王子兴, 姜晶梅, 于晓初. 基于Logistic回归模型的5类普外科并发症预测[J]. 基础医学与临床, 2023, 43(6): 974-980.
[10]	张雨, 韩悦, 朱倩梅, 周会影, 苗煦涵, 姚晶曼, 刘子嘉, 申乐. 老年患者电视胸腔镜手术后肺部并发症的危险因素分析[J]. 基础医学与临床, 2023, 43(12): 1847-1851.
[11]	蒋琪, 杨柳, 和娇娇, 李维辛. 脂毒性在肌少症发生发展中作用的研究进展[J]. 基础医学与临床, 2023, 43(12): 1886-1890.
[12]	李婷婷, 韩臻平, 高立, 王思懿, 钟恺, 黄萍, 严洁萍. 丙酮醛降低人脑微血管内皮细胞系hCMEC/D3细胞活力及线粒体膜电位[J]. 基础医学与临床, 2023, 43(11): 1631-1635.
[13]	余姿漫, 赵炳佳, 杨丹. JAK-STAT信号通路与糖尿病并发症的研究进展[J]. 基础医学与临床, 2023, 43(10): 1590-1593.
[14]	孙慧, 陈思宇. 微生物相关肿瘤的发病机制及其治疗的研究进展[J]. 基础医学与临床, 2023, 43(1): 178-182.
[15]	林柏柏, 钱风华, 钱义明, 赵雷, 孙旗, 褚梦瑶, 沈梦雯. 脓毒症并发毛细血管渗漏综合征的研究进展[J]. 基础医学与临床, 2022, 42(7): 1144-1147.