关键词: 糖尿病肾脏病, 真实世界研究, 数据挖掘, 用药经验

Abstract: Objective To summarize the prescription characteristics and medication rules for the treatment of diabetic kidney disease (DKD) from professor LIANG Xiaochun and to inherit professor LIANG Xiaochun′s academic anamnesis. Methods Using the retrospective real world research (RWS) method and the electronic medical record of Peking Union Medical Union Hospital Information System (HIS),the clinical records of DKD outpatient treatment by professor LIANG Xiaochun′s from 2020 to 2022 was collected to built a database with the support of Traditional Chinese Medicine inheritance computing platform (V3.5) software. Correlation analysis, cluster analysis and other methods were used to analyze the frequency of medication performance and the medication′s four natures, five flavors, meridian tropism, and the combination of commonly used drugs in the treatment of DKD were reviewed. Results A total of 205 cases covering 193 traditional Chinese medicines were collected. The most frequent use of drugs were Cuscutae Semen,Mori Cortex,Ligustri Lucidi Fructus,Achyranthes aspera Linn,Commelinae Herba,Smilacis Glabrae Rhizoma,Radix Et Rhizoma Rumei,Ramulus Euonymi Alati and Astmgali Radix. The four natures shared by them are cold and the five flavors are mostly sweetness. The meridian tropism belongs to the liver, spleen, and kidney. The analysis of drug association showed that the core drug combination was: Cuscutae Semen-Ligustri Lucidi Fructus,Cuscutae Semen-Achyranthes aspera Linn,Ligustri Lucidi Fructus-Achyranthes aspera Linn,Achyranthes aspera Linn-Smilacis Glabrae Rhizoma,Cuscutae Semen-Smilacis Glabrae Rhizoma etc. The four core prescriptions were obtained by cluster analysis: Cuscutae Semen-Ligustri Lucidi Fructus-Mori Cortex-Achyranthes aspera Linn-Smilacis Glabrae Rhizoma-Radix Et Rhizoma Rumei,Cuscutae Semen-Commelinae Herba-Mori Cortex-Achyranthes aspera Linn-Ligustri Lucidi Fructus-Smilacis Glabrae Rhizoma,Cuscutae Semen-Ligustri Lucidi Fructus-Mori Cortex-Commelinae Herba-Achyranthes aspera Linn-Radix Et Rhizoma Rumei,Mori Cortex-Ligustri Lucidi Fructus-Cuscutae Semen-Astmgali Radix-Smilacis Glabrae Rhizoma-Commelinae Herba. Conclusions Professor LIANG Xiaochun treated DKD with the principle of tonifying the spleen and kidney, promoting blood circulation, and removing turbidity. The experience of medication embodies the academic anamnesis the combination of tonifying kidney and solidifying astringency, the combination of removing turbidity and detoxifying supplemented by activating blood and water circulation in human body.

Key words: diabetic kidney disease(DKD), real world research, data mining, medication experience