免疫球蛋白用于原发性胆汁性胆管炎、戊型肝炎、肝硬化的鉴别诊断

doi:10.16352/j.issn.1001-6325.2023.08.1271

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (8): 1271-1274.doi: 10.16352/j.issn.1001-6325.2023.08.1271

免疫球蛋白用于原发性胆汁性胆管炎、戊型肝炎、肝硬化的鉴别诊断

邢雪梅¹, 杨建睿¹, 李治君¹, 陈雅娟¹, 姚凤霞², 刘征^3,4*

1.西安交通大学医学院附属三二〇一医院医学检验科,陕西汉中 723000;
2.中国医学科学院北京协和医学院北京协和医院疑难重症及罕见病国家重点实验室医学研究中心,北京 100730;
3.桂林医学院医学检验学院,广西桂林 541004;
4.遵义医科大学附属贵航贵阳医院医学检验科,贵州贵阳 550027

收稿日期:2022-06-10 修回日期:2022-10-11 出版日期:2023-08-05 发布日期:2023-07-26
通讯作者: ^*zliu1111@163.com
基金资助:
广西科技基地和人才专项基金(桂科AD19110161);广西自然科学基金(2018GXNSFAA281048)

Immunoglobulin is valuable in the differential diagnosis of primary biliary cholangitis, hepatitis E and cirrhosis

XING Xuemei¹, YANG Jianrui¹, LI Zhijun¹, CHEN Yajuan¹, YAO Fengxia², LIU Zheng^3,4*

1. Department of Medical Laboratory, the 3201st Hospital Affiliated to Medical College of Xi'an Jiaotong University, Hanzhong 723000;
2. Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, CAMS ＆ PUMC, Beijing 100730;
3. College of Medical Laboratory Science, Guilin Medical University, Guilin 541004;
4. Department of Medical Laboratory, Guihang Guiyang Hospital Affiliated to Zunyi Medical University, Guiyang 550027, China

Received:2022-06-10 Revised:2022-10-11 Online:2023-08-05 Published:2023-07-26
Contact: ^*zliu1111@163.com

摘要/Abstract

摘要： 目的探讨免疫球蛋白在原发性胆汁性胆管炎(PBC)、戊型肝炎、肝硬化鉴别诊断中的价值。方法收集121例PBC患者及107名健康人的血液样本。生化常规检测r-谷氨酰基转移酶(r-GT)、血清碱性磷酸酶(ALP)、免疫球蛋白IgG、免疫球蛋白IgM、总胆固醇(TCH)、脂蛋白(a)[Lp(a)]的数值;血常规计数白细胞(WBC)和血小板(PC);酶联免疫吸附实验(ELISA)检测HEV的IgG、IgM抗体。结果 PBC患者的r-GT、ALP、IgG、IgM显著升高(P＜0.05),伴随WBC、PC值的显著降低(P＜0.05)。PBC肝硬化患者的IgG显著升高(P＜0.05),WBC和PC值显著降低(P＜0.05)。PBC+肝硬化+HEV抗体阳性患者的IgG和IgM显著升高P＜0.05),同时WBC和PC值显著降低(P＜0.05)。结论 IgG和IgM升高可以作为PBC患者伴随HEV感染发展成肝硬化的诊断标志。

关键词: 戊型肝炎, 原发性胆汁性胆管炎, 肝硬化, IgG, IgM

Abstract: Objective To explore the value of immunoglobulin in differential diagnosis of primary biliary cholangitis (PBC), hepatitis E and liver cirrhosis. Methods Blood samples were collected from 121 patients with PBC and 107 healthy people. The serum r-glutamyltransferase (r-GT), alkaline phosphatase (ALP), immunoglobulin IgG and IgM, total cholesterol (TCH) and lipoprotein (a)[Lp(a)] were detected by biochemical routine tests; Blood routine counted white blood cells (WBC) and platelets (PC); The IgG and IgM antibodies of HEV were detected by enzyme-linked immunosorbent assay (ELISA). Results r-GT, ALP, IgG and IgM in PBC patients increased significantly (P＜0.05) accompanied by significant decrease in WBC and PC values (P＜0.05). In patients with PBC cirrhosis, IgG increased significantly (P＜0.05), while WBC and PC values decreased significantly(P＜0.05). IgG and IgM in patients with PBC+cirrhosis+HEV antibody positive increased significantly(P＜0.05), while WBC and PC values decreased significantly (P＜0.05). Conclusions The increase of IgG and IgM might be used as diagnostic markers for the development of cirrhosis in PBC patients with HEV infection.

Key words: hepatitis E, primary biliary cholangitis, cirrhosis, IgG, IgM

中图分类号:

邢雪梅, 杨建睿, 李治君, 陈雅娟, 姚凤霞, 刘征. 免疫球蛋白用于原发性胆汁性胆管炎、戊型肝炎、肝硬化的鉴别诊断[J]. 基础医学与临床, 2023, 43(8): 1271-1274.

XING Xuemei, YANG Jianrui, LI Zhijun, CHEN Yajuan, YAO Fengxia, LIU Zheng. Immunoglobulin is valuable in the differential diagnosis of primary biliary cholangitis, hepatitis E and cirrhosis[J]. Basic & Clinical Medicine, 2023, 43(8): 1271-1274.

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免疫球蛋白用于原发性胆汁性胆管炎、戊型肝炎、肝硬化的鉴别诊断

Immunoglobulin is valuable in the differential diagnosis of primary biliary cholangitis, hepatitis E and cirrhosis

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