基础医学与临床 ›› 2023, Vol. 43 ›› Issue (6): 974-980.doi: 10.16352/j.issn.1001-6325.2023.06.0974

• 研究论文 • 上一篇    下一篇

基于Logistic回归模型的5类普外科并发症预测

陈王跃1, 薛芳1, 韩伟1, 王子兴1, 姜晶梅1, 于晓初2*   

  1. 1.中国医学科学院基础医学研究所 北京协和医学院基础学院 流行病与卫生统计学系, 北京 100005;
    2.中国医学科学院 北京协和医学院 北京协和医院 肾内科,北京 100730
  • 收稿日期:2023-03-16 修回日期:2023-04-20 出版日期:2023-06-05 发布日期:2023-05-31
  • 通讯作者: *yuxch@pumch.cn
  • 基金资助:
    卫生部卫生行业专项(201402017)

Prediction of five types of general surgical complications based on Logistic regression model

CHEN Wangyue1, XUE Fang1, HAN Wei1, WANG Zixing1, JIANG Jingmei1, YU Xiaochu2*   

  1. 1. Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences CAMS,School of Basic Medicine PUMC, Beijing 100005;
    2. Department of Nephrology, Peking Union Medical College Hospital, CAMS & PUMC,Beijing 100730, China
  • Received:2023-03-16 Revised:2023-04-20 Online:2023-06-05 Published:2023-05-31
  • Contact: *yuxch@pumch.cn

摘要: 目的 基于一项多中心队列研究,描述普外科并发症发生情况,并建立不同类型并发症的预测模型。方法 基于《现代手术麻醉安全管理体系建设与推广项目》,选取2015年1月至6月和2016年1月至6月两阶段在4家医院实施普外科手术的患者作为研究对象,收集患者围术期资料;用多因素Logistic回归识别风险因素并进行预测。结果 19 223名患者中发生并发症的人数为830(4.32%)。其中,切口类并发症371人次(44.70%),瘘管类并发症190人次(22.89%),感染类并发症310人次(37.35%),衰竭类并发症161人次(19.40%),死亡104人(12.5%)。不同类型并发症的风险因素差异较大,切口、感染类和衰竭类并发症的风险因素覆盖整个围术期,瘘管类并发症主要集中于手术难度和术后的处理,对于死亡结局,术后因素相对术前因素风险较高。预测的曲线下面积在0.80~0.93之间。结论 在普外科中,不同类型并发症有各自的风险因素,针对性地建立预测模型可避免将并发症粗略简化而模糊各因素的影响程度,可为预防并发症提供参考。

关键词: 并发症, 普外科, 风险因素, 预测

Abstract: Objective To describe the occurrence of general surgical complications and establish prediction models for different types of complications based on a multicenter cohort study. Methods Based on Modern Surgery and Anesthesia Safety Management System Construction and Promotion(MSCP), patients who underwent general surgery in 4 hospitals from January to June 2015 and from January to June 2016 were selected as participants, and perioperative data of patients were collected. Logistic regression was used to identify risk factors and predict complications. Results Among 19 223 patients, 830(4.32%) had complications. Among participants who had complications, 371(44.70%) had incision complications, 190(22.89%) had fistula complications, 310(37.35%) had infection complications, 161(19.40%) had failure complications, and 104(12.5%) died. There were significant differences in the risk factors of different types of complications. The risk factors of incision,infection and failure covered the whole perioperative period, while fistula complications mainly focused on the difficulty of surgery and postoperative treatment, and for death outcomes, postoperative risk factors were more severe than preoperative risk factors. The areas under the curves of prediction were between 0.80-0.93. Conclusions In general surgery, different types of complications have different risk factors. The targeted prediction model can avoid the rough simplification of complications and fuzzy influence of each factor, and can provide reference for the prevention of complications.

Key words: complications, general surgery department, risk factors, prediction

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