11β-HSD1在炎性反应、肝癌的发生发展与免疫中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.05.0837

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (5): 837-841.doi: 10.16352/j.issn.1001-6325.2023.05.0837

11β-HSD1在炎性反应、肝癌的发生发展与免疫中作用的研究进展

雷星煜¹, 冯雪松¹, 晁旭^1,2*

1.陕西中医药大学基础医学院,陕西咸阳 712046;
2.陕西中医药大学第二附属医院,陕西西安 712000

收稿日期:2022-12-12 修回日期:2023-03-21 出版日期:2023-05-05 发布日期:2023-04-26
通讯作者: ^*172665861@qq.com
基金资助:
陕西省中医药管理局科研项目(2021-zz-JC001);陕西省教育厅一般项目(20JK0588)

Progress on the role of 11β-HSD1 in inflammation,development of hepatocellular carcinoma and immunity

LEI Xingyu¹, FENG Xuesong¹, CHAO Xu^1,2*

1. College of Basic Medicine Sciences, Shaanxi University of Chinese Medicine, Xianyang 712046;
2. The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xi'an 712000, China

Received:2022-12-12 Revised:2023-03-21 Online:2023-05-05 Published:2023-04-26
Contact: ^*172665861@qq.com

摘要/Abstract

摘要： 11β-羟基类固醇脱氢酶1(11β-HSD1)在与代谢有关的炎性疾病,以及免疫中可通过调节糖皮质激素(GC)的合成发挥抗炎或促炎作用。11β-HSD1的整体表达和活性可受促炎细胞因子的诱导,这一过程依赖于NF-κB信号通路并由其基因(HSD11B1)P1和P2启动子的利用水平最终决定。此外,11β-HSD1在肝细胞癌中通过降低葡萄糖摄入和糖酵解抑制肝细胞癌的增殖,并通过调节GC的水平参与胸腺中T细胞的发育和血管生成。了解11β-HSD1在炎性疾病、癌的发生发展、免疫中的分子调控机制有利于探究相关疾病的发生发展。

关键词: 11β-羟基类固醇脱氢酶(11β-HSD1), 炎性反应, 癌的发生发展, 免疫

Abstract: The 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) with anti-inflammatory or pro-inflammatory effects in inflammatory diseases is related to metabolism, as well as in the immune response through regulatpn of glucocorticoid (GC) synthesis. The expression and functional activity of 11β-HSD1 are potentially induced by pro-inflammatory cytokines, this process relies on the NF-κB signaling pathway and is ultimately determined by the utilization levels of HSD11B1 P1 and P2 promoters. In addition, 11β-HSD1 inhibits the proliferation of hepatocellular carcinoma by reducing glucose intake and glycolysis in hepatocellular carcinoma, and thus plays a role in the development of T cells in thymus and the form of angiogenesis by regulating the level of GC. Understanding the molecular regulatory mechanism of 11β-HSD1 in inflammatory diseases, carcinogenesis, development and immune response is conducive to exploring the occurrence and development of related diseases.

Key words: 11β-hydroxysteroid dehydrogenase 1(11β-HSD1), inflammation, carcinogenesis, immunity

中图分类号:

雷星煜, 冯雪松, 晁旭. 11β-HSD1在炎性反应、肝癌的发生发展与免疫中作用的研究进展[J]. 基础医学与临床, 2023, 43(5): 837-841.

LEI Xingyu, FENG Xuesong, CHAO Xu. Progress on the role of 11β-HSD1 in inflammation,development of hepatocellular carcinoma and immunity[J]. Basic & Clinical Medicine, 2023, 43(5): 837-841.

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11β-HSD1在炎性反应、肝癌的发生发展与免疫中作用的研究进展

Progress on the role of 11β-HSD1 in inflammation,development of hepatocellular carcinoma and immunity

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