RhoGTP酶活化蛋白在上皮细胞间质转化中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.02.301

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (2): 301-305.doi: 10.16352/j.issn.1001-6325.2023.02.301

RhoGTP酶活化蛋白在上皮细胞间质转化中作用的研究进展

徐倩, 段华^*, 甘露, 刘麒薇

首都医科大学附属北京妇产医院妇科微创中心,北京 100006

收稿日期:2021-07-28 修回日期:2022-01-07 出版日期:2023-02-05 发布日期:2023-02-02
通讯作者: ^*duanhua@ccmu.edu.cn
基金资助:
国家自然科学基金青年科学基金(81801403);首都医科大学附属北京妇产医院中青年学科骨干培养专项(FCYY201823)

Research progress of RhoGTPase activating protein in epithelial-mesenchymal transition

XU Qian, DUAN Hua^*, GAN Lu, LIU Qiwei

Department of Gynecology Minimally Invasive Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100006, China

Received:2021-07-28 Revised:2022-01-07 Online:2023-02-05 Published:2023-02-02
Contact: ^*duanhua@ccmu.edu.cn

摘要/Abstract

摘要： 上皮细胞间质转化(EMT)是指上皮细胞在形态上发生向间(充)质细胞表型的转变,并获得迁移能力,其在肿瘤细胞侵袭及纤维化疾病的形成中起着重要作用。RhoGTP酶活化蛋白(RhoGAP)可以通过参与调控细胞表面受体同肌动蛋白细胞骨架的信号传导,影响EMT相关的肿瘤转移及组织纤维化转归,为后续寻找抗肿瘤及抗纤维化的治疗靶点提供分子诊疗思路。

关键词: RhoGTP酶活化蛋白, 上皮细胞间质转化, 肌动蛋白细胞骨架, 肿瘤转移, 纤维化疾病

Abstract: Epithelial-mesenchymal transition (EMT) is a process by which epithelial cells undergo morphological changes to gain a mesenchymal cell phenotype and migratory properties. As a class of negative regulators of RhoGTPases, RhoGTPase activating proteins(RhoGAP) can bridge between cell surface receptors and cellular actin cytoskeleton during EMT procedure, which may influence cancer cell transition and outcome of fibrotic diseases and may help search for anti-tumor and anti-fibrotic managements.

Key words: RhoGTPase activating protein, epithelial-mesenchymal transition, actin cytoskeleton, metastasis, fibrotic diseases

中图分类号:

徐倩, 段华, 甘露, 刘麒薇. RhoGTP酶活化蛋白在上皮细胞间质转化中作用的研究进展[J]. 基础医学与临床, 2023, 43(2): 301-305.

XU Qian, DUAN Hua, GAN Lu, LIU Qiwei. Research progress of RhoGTPase activating protein in epithelial-mesenchymal transition[J]. Basic & Clinical Medicine, 2023, 43(2): 301-305.

参考文献 24

[1]	Dalla PE, Forciniti S, Palmieri M, et al. Secreted molecules inducing epithelial-to-mesenchymal transition in cancer development[J]. Semin Cell Dev Biol,2018,78:62-72.
[2]	Kolb K, Hellinger J, Kansy M, et al. Influence of ARHGAP29 on the invasion of mesenchymal-transformed breast cancer cells[J]. Cells,2020,9.doi: 10.3390/cells9122616.
[3]	Correll KA, Edeen KE, Zemans RL, et al. Transitional human alveolar type Ⅱ epithelial cells suppress extracel-lular matrix and growth factor gene expression in lung fibroblasts[J]. Am J Physiol Lung Cell Mol Physiol,2019,317:L283-L294.
[4]	吴娜,王东,李京敏,等. 羟基红花黄色素A抑制人肝癌细胞系Huh7发生上皮-间质转化[J]. 基础医学与临床,2021,41:1423-1427.
[5]	Aspenstrom P. The intrinsic GDP/GTP exchange activities of Cdc42 and Rac1 are critical determinants for their specific effects on mobilization of the actin filament system[J]. Cells,2019,8. doi: 10.3390/cells8070759.
[6]	Svensmark JH, Brakebusch C. Rho GTPases in cancer: friend or foe?[J]. Oncogene,2019,38:7447-7456.
[7]	Lawson CD, Ridley AJ. Rho GTPase signaling complexes in cell migration and invasion[J]. J Cell Biol,2018,217:447-457.
[8]	Bagci H, Sriskandarajah N, Robert A, et al. Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms[J]. Nat Cell Biol,2020,22:120-134.
[9]	Pannekoek WJ, Vliem MJ, Bos JL. Multiple Rap1 effectors control Epac1-mediated tightening of endothelial junctions[J]. Small GTPases,2020,11:346-353.
[10]	Zhang K, Na T, Ge F, et al. DLC-1 tumor suppressor regulates CD105 expression on human non-small cell lung carcinoma cells through inhibiting TGF-beta1 signaling[J]. Exp Cell Res,2020,386:111732. doi: 10.1016/j.yexcr.2019.111732.
[11]	Liu H, Liu Y, Sun P, et al. Colorectal cancer-derived exosomal miR-106b-3p promotes metastasis by down-regulating DLC-1 expression[J]. Clin Sci (Lond),2020,134:419-434.
[12]	Huang W, Liu J, Feng X, et al. DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-kappaB pathway[J]. Med Oncol,2015,32:115.doi: 10.1007/s12032-015-0564-4.
[13]	Ravi A, Kaushik S, Ravichandran A, et al. Epidermal growth factor activates the Rho GTPase-activating protein (GAP) deleted in liver cancer 1 via focal adhesion kinase and protein phosphatase 2A[J]. J Biol Chem,2015,290:4149-4162.
[14]	Bidaud-Meynard A, Biname F, Lagree V, et al. Regula-tion of Rho GTPase activity at the leading edge of migrating cells by p190RhoGAP[J]. Small GTPases,2019,10:99-110.
[15]	Ouyang H, Luong P, Frodin M, et al. p190A RhoGAP induces CDH1 expression and cooperates with E-cadherin to activate LATS kinases and suppress tumor cell growth[J]. Oncogene,2020,39:5570-5587.
[16]	Frank SR, Kollmann CP, Luong P, et al. p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity[J]. J Cell Biol,2018,217:3183-3201.
[17]	Tian T, Chen ZH, Zheng Z, et al. Investigation of the role and mechanism of ARHGAP5-mediated colorectal cancer metastasis[J]. Theranostics, 2020, 10:5998-6010.
[18]	Hanley PJ, Vollmer V, Bahler M. Class Ⅸ myosins: motorized RhoGAP signaling molecules[J]. Adv Exp Med Biol,2020,1239:381-389.
[19]	Hemkemeyer SA, Vollmer V, Schwarz V, et al. Local Myo9b RhoGAP activity regulates cell motility[J]. J Biol Chem,2021,296: 100136. doi: 10.1074/jbc.RA120.013623.
[20]	Qian X, Hua D, Lu G, et al. MicroRNA-1291 promotes the endometrial fibrosis by regulating ArhGAP29-RhoA/ROCK1 signaling pathway in a murine model[J].Mol Med Rep, 2017, 16: 4501-4510.
[21]	李天柱,史铁伟,周静,等. 干扰ELK-3抑制人肝癌细胞的上皮-间质转换[J]. 基础医学与临床,2017,37:211-216.
[22]	Wang L, Shen S, Xiao H, et al. ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-p27 axis[J]. Carcinogenesis,2020,41:711-721.
[23]	Chao H, Zhang M, Hou H, et al. HOTAIRM1 suppresses cell proliferation and invasion in ovarian cancer through facilitating ARHGAP24 expression by sponging miR-106a-5p[J]. Life Sci,2020,243:117296.doi: 10.1016/j.lfs.2020.117296.
[24]	Brakebusch C. Rho GTPase signaling in health and disease: acomplex signaling network[J]. Cells,2021,10:401.doi: 10.3390/cells10020401.

RhoGTP酶活化蛋白在上皮细胞间质转化中作用的研究进展

Research progress of RhoGTPase activating protein in epithelial-mesenchymal transition

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