神经调节蛋白4调节脂代谢的研究进展

doi:10.16352/j.issn.1001-6325.2023.10.1599

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (10): 1599-1603.doi: 10.16352/j.issn.1001-6325.2023.10.1599

神经调节蛋白4调节脂代谢的研究进展

王雪冉, 田宗源, 刘瑞霞^*

首都医科大学附属北京妇产医院/北京妇幼保健院中心实验室, 北京 100026

收稿日期:2022-11-13 修回日期:2023-04-10 出版日期:2023-10-05 发布日期:2023-10-05
通讯作者: *liuruixia@ccmu.edu.cn
基金资助:
首都临床特色应用研究(Z181100001718076)

Research progress on neuregulin 4 regulating lipid metabolism

WANG Xueran, TIAN Zongyuan, LIU Ruixia^*

Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China

Received:2022-11-13 Revised:2023-04-10 Online:2023-10-05 Published:2023-10-05
Contact: *liuruixia@ccmu.edu.cn

摘要/Abstract

摘要： 神经调节蛋白4(NRG4)是一种新型脂肪分泌因子,主要在棕色脂肪表达及分泌。NRG4与肝细胞膜上表皮生长因子受体4(ErbB4)特异性结合,激活下游信号通路,抑制脂质的从头合成,增加脂肪酸氧化及生酮作用,减弱肝脂肪变性。NRG4还可调控脂肪组织基因的表达,降低脂肪细胞的胰岛素抵抗,调节脂肪组织中血管重塑,维持脂代谢平衡。NRG4对脂质的有益调节有助于改善与肥胖相关的代谢性紊乱,可能成为非酒精性脂肪肝、糖尿病和动脉粥样硬化等疾病的潜在治疗靶点。

关键词: 神经调节蛋白4, 脂代谢, 脂肪组织

Abstract: Neuregulin 4 (NRG4) is a novel fat secretion factor that is mainly expressed and secreted in brown fat. NRG4 specifically binds to epidermal growth factor receptor 4 (ErbB4) on hepatocyte membranes and activates downstream signaling pathways to relieve hepatic steatosis by inhibiting de novo synthesis of lipids, increasing fatty acid oxidation and ketogenesis. NRG4 can also regulate the expression of adipose tissue genes, reduce the insulin resistance of adipocytes, regulate vascular remodeling in adipose tissue, and benefit lipid metabolism. The favorable regulation of lipids by NRG4 may improve obesity-related metabolic disorders and might be a potential therapeutic target for metabolic diseases such as non-alcoholic fatty liver, diabetes, and atherosclerosis.

Key words: neuregulin 4(NRG4), lipid metabolism, adipose tissue

中图分类号:

王雪冉, 田宗源, 刘瑞霞. 神经调节蛋白4调节脂代谢的研究进展[J]. 基础医学与临床, 2023, 43(10): 1599-1603.

WANG Xueran, TIAN Zongyuan, LIU Ruixia. Research progress on neuregulin 4 regulating lipid metabolism[J]. Basic & Clinical Medicine, 2023, 43(10): 1599-1603.

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神经调节蛋白4调节脂代谢的研究进展

Research progress on neuregulin 4 regulating lipid metabolism

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