基础医学与临床 ›› 2022, Vol. 42 ›› Issue (9): 1438-1442.doi: 10.16352/j.issn.1001-6325.2022.09.1438

• 短篇综述 • 上一篇    下一篇

雌激素及其受体协同HPV在宫颈癌肿瘤微环境中作用的研究进展

李贺同, 任晶晶, 王文豪, 郝敏*   

  1. 山西医科大学第二医院 妇产科,山西 太原 030001
  • 收稿日期:2021-12-13 修回日期:2022-05-06 出版日期:2022-09-05 发布日期:2022-09-02
  • 通讯作者: 2yuanhaomin@163.com
  • 基金资助:
    国家自然科学基金(81972452);山西省研究生创新项目(2021Y385)

Advances in the study of the role of estrogen and its receptor combined with HPV in cervical cancer microenvironment

LI He-tong, REN Jing-jing, WANG Wen-hao, HAO Min*   

  1. Department of Obstetrics and Gynecology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2021-12-13 Revised:2022-05-06 Online:2022-09-05 Published:2022-09-02

摘要: 宫颈癌发生与人乳头瘤病毒(HPV)感染有关,雌激素及其受体与HPV癌基因联合可促进宫颈癌发展,高产次及避孕药的使用增加宫颈癌发病风险支持雌激素和HPV感染协同促进宫颈癌。雌激素可作用于HPV反应元件使HPV的基因表达改变,进而加速HPV感染进程,同时也可通过在肿瘤微环境中发挥免疫调节作用促进HPV阳性宫颈癌发生发展。雌激素及其受体对宫颈癌的发生有重要作用,并有望成为宫颈癌潜在治疗靶点。

关键词: 雌激素, 雌激素受体, 宫颈肿瘤, 治疗, 选择性雌激素受体拮抗剂

Abstract: Human papillomavirus (HPV) infection is related to cervical cancer. Estrogen and its receptor combined with HPV oncogene can promote the occurrence of cervical cancer. Moreover, high parity and the use of contraceptives incrcasing the risk of cervical cancer support estrogen and HPV infection synergistically promotes cervical cancer. Estrogen can both combine with HPV responsive elements to change viral gene expression accelerating the process of HPV infection, and develop HPV-positive cervical cancer by exerting immunomodulatory function in tumor microenvironment. Estrogen and its receptor play vital roles in cervical cancer and are expected to be a potential therapeutic target for treatment of cervical cancer.

Key words: estrogen, estrogen receptor, uterine cervical neoplasms, therapy, selective estrogen receptor antagonist

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