“起立-行走”计时测试表现与中国华东地区老年人认知障碍相关

doi:10.16352/j.issn.1001-6325.2022.07.1042

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (7): 1042-1046.doi: 10.16352/j.issn.1001-6325.2022.07.1042

“起立-行走”计时测试表现与中国华东地区老年人认知障碍相关

刘延丽¹, 马雅军², 潘燕², 赵瑞雪², 赵暾², 蒋晓燕³, 李淑娟^4*

1.北京怀柔医院神经内科,北京 101400;
2.首都医科大学附属北京朝阳医院神经内科,北京 100020;
3.同济大学医学院病理学与病理生理学系心律失常教育部重点实验室,上海 200092;
4.中国医学科学院北京协和医学院国家心血管疾病中心阜外医院神经内科,北京 100034

收稿日期:2022-04-07 修回日期:2022-05-19 出版日期:2022-07-05 发布日期:2022-06-29
通讯作者: * lishujuan@fuwai.com
基金资助:
国家重点研发计划(2018YFC2000400,2018YFC2002000);国家自然科学基金(81971102)

Timed Up and Go test is associated with cognitive impairment in elders from East China

LIU Yan-li¹, MA Ya-jun², PAN Yan², ZHAO Rui-xue², ZHAO Tun², JIANG Xiao-yan³, LI Shu-juan^4*

1. Department of Neurology, Beijing Huairou District Hospital, Beijing 101400;
2. Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020;
3. Key Laboratory of Arrhythmias, Ministry of Education, Department of Pathology and Pathophysiology, School of Medicine, Tongji University, Shanghai 200092;
4. Department of Neurology, Fuwai Hospital, National Center for Cardiovascular Diseases, CAMS & PUMC, Beijing 100034, China

Received:2022-04-07 Revised:2022-05-19 Online:2022-07-05 Published:2022-06-29
Contact: * lishujuan@fuwai.com

摘要/Abstract

摘要： 目的本研究旨在探索“起立-行走”计时(TUG)测试表现与老年人认知功能的相关性。方法研究对象为江苏省如皋市长寿与老化研究队列。完成TUG测试,记录测试时间、步态稳定性和综合评分。采用中文版长谷川痴呆量表(HDS-R) 评估认知功能。结果共1 655名受试者(年龄75~84岁)完成TUG测试并进行认知评估纳入本研究。其中认知障碍组872例(52.7%),非认知障碍组783例(47.3%),TUG测试时间、步态稳定性和综合评分分别与HDS-R评分及其子成分呈负相关(P＜0.001)。Logistic回归分析显示,TUG测试时间较长(OR=2.50,95% CI:1.76~3.55, P＜0.001)、步态不稳(OR=1.11,95% CI:1.08~1.14, P＜0.001)和综合评分差(OR=1.62, 95% CI:1.39-1.89, P＜0.001)与认知障碍风险增加独立相关。结论 TUG测试中运动功能表现较差与认知功能障碍显著相关,TUG测试应用于社区的认知障碍早期风险筛查具有一定的可行性。

关键词: 认知障碍, 运动功能, “起立-行走”计时(TUG)测试, 衰老, 衰退

Abstract: Objective To explore a potential relationship of Timed Up and Go (TUG) test to cognitive functions among elders. Methods The participants were from Rugao Longevity and Ageing Study conducted in Jiangsu province, China. TUG test was completed, recording gaits stability, test time and the overall scale. Cognitive function was evaluated using Chinese version of revised Hasegawa's Dementia Scale (HDS-R). Results A total of 1 655 participants (aged 75-84 years old) completed the TUG test and cognitive evaluation were included in this study. Among them, 872(52.7%) in cognitive impairment group and 783(47.3%) in non-cognitive impairment group, the gait stability, time and scale of TUG test were inverse associated with HDS-R and its subcomponents, respectively(P＜0.001). Logistic regression analysis showed that unsteady gait(OR=1.11, 95% CI:1.08-1.14, P＜0.001), longer time (OR=2.50, 95% CI:1.76-3.55, P＜0.001) and deteriorated scale (OR=1.62, 95% CI:1.39-1.89, P＜0.001) in TUG test were independently associated with increased risk of cognitive impairment. Conclusions Worse motor function performance on TUG test is significantly associated with cognitive impairment. The application of TUG test is potential method in early risk screening of cognitive impairment in community and has certain feasibility.

Key words: cognitive impairment, motor function, Timed Up and Go (TUG) test, aging, decline

中图分类号:

R741

刘延丽, 马雅军, 潘燕, 赵瑞雪, 赵暾, 蒋晓燕, 李淑娟. “起立-行走”计时测试表现与中国华东地区老年人认知障碍相关[J]. 基础医学与临床, 2022, 42(7): 1042-1046.

LIU Yan-li, MA Ya-jun, PAN Yan, ZHAO Rui-xue, ZHAO Tun, JIANG Xiao-yan, LI Shu-juan. Timed Up and Go test is associated with cognitive impairment in elders from East China[J]. Basic & Clinical Medicine, 2022, 42(7): 1042-1046.

参考文献 15

[1]	Rajtar-Zembaty A, Salakowski A, Rajtar-Zembaty J, et al. Slow gait as a motor marker of mild cognitive impairment? the relationships between functional mobility and mild cognitive impairment[J]. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn,2019, 26: 521-530.
[2]	Darweesh SKL, Licher S, Wolters FJ, et al. Quantitative gait, cognitive decline, and incident dementia: the rotterdam study[J]. Alzheimers Dement,2019, 15: 1264-1273.
[3]	Savica R, Wennberg AM, Hagen C, et al. Comparison of gait parameters for predicting cognitive decline: the Mayo clinic study of aging[J]. J Alzheimers Dis,2017, 55: 559-567.
[4]	Chou MY, Nishita Y, Nakagawa T, et al. Role of gait speed and grip strength in predicting 10-year cognitive decline among community-dwelling older people[J]. BMC Geriatr,2019, 19: 186.doi:10.1186/s12877-019-1199-7.
[5]	Jayakody O, Breslin M, Srikanth VK, et al. Gait characteristics and cognitive decline: a longitudinal population-based study[J]. J Alzheimers Dis,2019, 71: S5-S14.
[6]	Jayakody O, Breslin M, Ayers E, et al. Relative trajecto-ries of gait and cognitive decline in aging[J]. J Gerontol A Biol Sci Med Sci,2021, 11: glab346.doi:10.1093/gerona/glab346.
[7]	Liu Z, Wang Y, Zhang Y, et al. Cohort profile: the Rugao longevity and ageing study (RuLAS)[J]. Int J Epidemiol,2016, 45: 1064-1073.
[8]	Zhi T, Wang Q, Liu Z, et al. Body mass index, waist circumference and waist-hip ratio are associated with depressive symptoms in older Chinese women: results from the Rugao Longevity and Ageing Study (RuLAS)[J]. Aging Ment Health,2017, 21: 518-523.
[9]	Li YX, Jiang XY, Stone C, et al. A new physical-cognitive scale for assessment of frailty in Chinese Han elderly[J]. Neurol Res,2019, 41: 728-733.
[10]	Sprint G, Cook DJ, Weeks DL. Toward automating clinical assessments: a survey of the timed up and go[J]. IEEE Rev Biomed Eng,2015, 8: 64-77.
[11]	Vseteckova J, Deepak-Gopinath M, Borgstrom E, et al. Barriers and facilitators to adherence to group exercise in institutionalized older people living with dementia: a systematic review[J]. Eur Rev Aging Phys Act,2018, 15: 11.
[12]	Bahureksa L, Najafi B, Saleh A, et al. The impact of mild cognitive impairment on gait and balance: a systematic review and meta-analysis of studies using instrumented assessment[J]. Gerontology,2017, 63: 67-83.
[13]	Kuan YC, Huang LK, Wang YH, et al. Balance and gait performance in older adults with early-stage cognitive impairment[J]. Eur J Phys Rehabil Med,2021, 57: 560-567.
[14]	Toots ATM, Taylor ME, Lord SR, et al. Associations between gait speed and cognitive domains in older people with cognitive impairment[J]. J Alzheimers Dis,2019, 71: S15-S21.
[15]	Donoghue OA, Horgan NF, Savva GM, et al. Association between timed up-and-go and memory, executive func-tion, and processing speed[J]. J Am Geriatr Soc,2012, 60: 1681-1686.

“起立-行走”计时测试表现与中国华东地区老年人认知障碍相关

Timed Up and Go test is associated with cognitive impairment in elders from East China

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 15

相关文章 15

编辑推荐

Metrics

本文评价

[1]	龚金涛, 厉建伟, 李玉恒, 李堑, 赵春华. 骨髓间充质干细胞缓解模拟微重力对小鼠大脑皮质的不利影响[J]. 基础医学与临床, 2024, 44(6): 772-778.
[2]	高竞溪, 赵晓妍, 朱星雨, 孙昭, 韩钦, 赵春华. BM-MSCs延缓CD8⁺初始T细胞衰老[J]. 基础医学与临床, 2024, 44(5): 683-689.
[3]	魏丹丹, 宋宇涵, 王淇, 宿树兰, 朱悦, 段金廒. 年龄相关性黄斑变性的研究进展[J]. 基础医学与临床, 2024, 44(4): 553-557.
[4]	柴亚如, 邓玉婷, 戴红艳, 管军. Klotho在心力衰竭中作用的研究进展[J]. 基础医学与临床, 2023, 43(6): 998-1002.
[5]	卢琰, 周雅博, 陈洁. 利用类器官培养构建小鼠肝脏衰老模型[J]. 基础医学与临床, 2023, 43(4): 554-559.
[6]	商利鹏, 刘国祥, 丁晓燕, 李冰, 赵春华, 李霄霞. 间充质干细胞在衰老相关疾病应用中的研究进展[J]. 基础医学与临床, 2023, 43(1): 38-45.
[7]	祝思路, 罗丹. 干细胞衰老的研究进展[J]. 基础医学与临床, 2022, 42(8): 1288-1291.
[8]	何盛梅, 赵厚育. NAD⁺代谢在细胞功能及相关疾病中作用的研究进展[J]. 基础医学与临床, 2022, 42(2): 306-310.
[9]	袁景林, 赵瑞雪, 李晓东, 蒋晓燕, 王笑峰, 周晓梅, 李淑娟. 运动认知风险综合征增加老年人住院风险[J]. 基础医学与临床, 2021, 41(8): 1169-1173.
[10]	赵瑞雪, 马雅军, 刘惠, 李晓东, 王笑峰, 蒋晓燕, 李淑娟. 认知衰弱诊治的研究进展[J]. 基础医学与临床, 2021, 41(6): 895-898.
[11]	杨齐, 许峰, 焦阳, 张赛, 孙中磊. TREM2过表达减轻大鼠颅脑创伤后的认知缺陷[J]. 基础医学与临床, 2021, 41(12): 1724-1729.
[12]	张良, 刘明永, 刘鹏, 薛鑫, 张良民, 郭乔楠, 赵建华. 骨肉瘤细胞脱逸化疗诱导的细胞衰老可重新增殖成瘤细胞[J]. 基础医学与临床, 2020, 40(2): 187-191.
[13]	钟志胜, 洪雯丽, 曹秀萍, 聂坤, 唐子娟, 谢奇, 李佳. 雌性生殖干细胞衰老相关因素及延缓措施的研究进展[J]. 基础医学与临床, 2020, 40(11): 1546-1550.
[14]	黄铭江韩薇. Sestrins延缓衰老作用的研究进展[J]. 基础医学与临床, 2018, 38(12): 1786-1790.
[15]	周茜李浩. Glymphatic系统与认知障碍相关疾病的研究进展[J]. 基础医学与临床, 2018, 38(10): 1457-1460.