基础医学与临床 ›› 2022, Vol. 42 ›› Issue (11): 1767-1770.doi: 10.16352/j.issn.1001-6325.2022.11.1767

• 短篇综述 • 上一篇    下一篇

分泌蛋白Metrnl在不同疾病中作用的研究进展

张蓝月, 张学东*   

  1. 重庆医科大学附属第一医院 眼科, 重庆 400000
  • 收稿日期:2021-05-24 修回日期:2021-11-12 出版日期:2022-11-05 发布日期:2022-11-01
  • 通讯作者: * 370074@qq.com
  • 基金资助:
    国家自然科学基金(818704093)

Research progress on the role of secretory protein Metrnl in different diseases

ZHANG Lan-yue, ZHANG Xue-dong*   

  1. Department of Ophthalmology,the First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China
  • Received:2021-05-24 Revised:2021-11-12 Online:2022-11-05 Published:2022-11-01
  • Contact: * 370074@qq.com

摘要: 镍纹样蛋白(Metrnl)是一种与神经营养因子Meteorin同源的新的细胞因子,也是一种分泌蛋白,其基因及产物表现为低组织特异性,在体内广泛表达。该蛋白可类似神经营养因子、脂肪因子、炎性因子及肌肉因子,在机体神经发育、免疫炎性反应、代谢等多方面发挥作用。

关键词: 镍纹样蛋白(Metrnl), 神经营养因子, 能量代谢, 胰岛素抵抗, 免疫调节

Abstract: Metrnl is a new cytokine with homologous orignination from neurotrophic factor Meteorin. Meanwhile, as a secreting protein, its gene and products show low tissue specificity and is widely expressed in different tissues of host. Similar to neurotrophic factor, adipocytokines, inflammatory factor and muscle factor, the protein plays a role in neural development, immune inflammatory response and metabolism and so on.

Key words: Meteorin-like protein(Metrnl), neurotrophic factor, energy metabolism, insulin resistance, immunoregulation

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